T R Gingeras
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Explore the profile of T R Gingeras including associated specialties, affiliations and a list of published articles.
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51
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3950
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Recent Articles
1.
Willingham A, Dike S, Cheng J, Manak J, Bell I, Cheung E, et al.
Cold Spring Harb Symp Quant Biol
. 2007 May;
71:101-10.
PMID: 17480199
Regions of the genome not coding for proteins or not involved in cis-acting regulatory activities are frequently viewed as lacking in functional value. However, a number of recent large-scale studies...
2.
Rozowsky J, Wu J, Lian Z, Nagalakshmi U, Korbel J, Kapranov P, et al.
Cold Spring Harb Symp Quant Biol
. 2007 Mar;
71:111-6.
PMID: 17381286
We have used genomic tiling arrays to identify transcribed regions throughout the human genome. Analysis of the mapping results of RNA isolated from five cell/tissue types, NB4 cells, NB4 cells...
3.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith M, Maeda N, et al.
Science
. 2005 Sep;
309(5740):1559-63.
PMID: 16141072
This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3'...
4.
Rosenow C, Saxena R, Durst M, Gingeras T
Nucleic Acids Res
. 2001 Nov;
29(22):E112.
PMID: 11713332
High density oligonucleotide arrays have been used extensively for expression studies of eukaryotic organisms. We have designed a prokaryotic high density oligonucleotide array using the complete Escherichia coli genome sequence...
5.
Ehrt S, Schnappinger D, Bekiranov S, Drenkow J, Shi S, Gingeras T, et al.
J Exp Med
. 2001 Oct;
194(8):1123-40.
PMID: 11602641
Macrophage activation determines the outcome of infection by Mycobacterium tuberculosis (Mtb). Interferon-gamma (IFN-gamma) activates macrophages by driving Janus tyrosine kinase (JAK)/signal transducer and activator of transcription-dependent induction of transcription and...
6.
Dong S, Wang E, Hsie L, Cao Y, Chen X, Gingeras T
Genome Res
. 2001 Aug;
11(8):1418-24.
PMID: 11483583
A method for identifying and validating single nucleotide polymorphisms (SNPs) with high-density oligonucleotide arrays without the need for locus-specific polymerase chain reactions (PCR) is described in this report. Genomic DNAs...
7.
Kato-Maeda M, Rhee J, Gingeras T, Salamon H, Drenkow J, Smittipat N, et al.
Genome Res
. 2001 Apr;
11(4):547-54.
PMID: 11282970
The study of genetic variability within natural populations of pathogens may provide insight into their evolution and pathogenesis. We used a Mycobacterium tuberculosis high-density oligonucleotide microarray to detect small-scale genomic...
8.
Salamon H, Kato-Maeda M, Small P, Drenkow J, Gingeras T
Genome Res
. 2000 Dec;
10(12):2044-54.
PMID: 11116098
Genomic diversity within and between populations is caused by single nucleotide mutations, changes in repetitive DNA systems, recombination mechanisms, and insertion and deletion events. The contribution of these sources to...
9.
Belcher C, Drenkow J, Kehoe B, Gingeras T, McNamara N, Lemjabbar H, et al.
Proc Natl Acad Sci U S A
. 2000 Nov;
97(25):13847-52.
PMID: 11087813
Bordetella pertussis, the causative agent of whooping cough, has many well-studied virulence factors and a characteristic clinical presentation. Despite this information, it is not clear how B. pertussis interaction with...
10.
Hu J, Durst M, Kerb R, Truong V, Ma J, Khurgin E, et al.
Ann N Y Acad Sci
. 2000 Nov;
919:9-15.
PMID: 11083092
An important aspect of the drug development process is prediction of efficacious and toxic side effects. Profiling of mRNA expression is a powerful approach to analyze the molecular phenotype of...