T R Downs
Overview
Explore the profile of T R Downs including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
42
Citations
328
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Downs T, Dage R, French J
Int J Immunopharmacol
. 1995 Jul;
17(7):571-80.
PMID: 8586485
Multiple organ dysfunction (MOD) is the leading cause of mortality in septic patients with circulatory shock. Recent evidence suggests that the overproduction of the cytokine, tumor necrosis factor-alpha(TNF), and oxygen...
2.
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase in rats with hypertension
French J, Anderson B, Downs T, Dage R
J Cardiovasc Pharmacol
. 1995 Jul;
26(1):107-13.
PMID: 7564349
Angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP), are two mechanistically similar enzymes involved in the metabolism of several vasoactive peptides. Selective inhibitors of ACE are effective antihypertensive agents in...
3.
Mizobuchi M, Downs T, Frohman L
Endocrinology
. 1995 Apr;
136(4):1731-6.
PMID: 7895684
The GH-releasing hormone (GRH) gene, along with those of many other hypothalamic hormones, is abundantly expressed in mouse and rat placenta. The presence of GRH immunoreactivity (GRH-IR) is described in...
4.
French J, Thomas C, Downs T, Ohlweiler D, CARR A, Dage R
Circ Shock
. 1994 Jul;
43(3):130-6.
PMID: 7850933
Evidence of a role for oxygen-derived free radicals in the pathophysiology of endotoxic shock has been found in animal models. However, the importance of free radicals in chronic models of...
5.
Pecori Giraldi F, Mizobuchi M, Horowitz Z, Downs T, Aleppo G, Kier A, et al.
Endocrinology
. 1994 Mar;
134(3):1219-24.
PMID: 8119162
Expression of the mouse GH-releasing hormone (GRH) gene is restricted to neurons within the hypothalamus and to placenta. In an attempt to generate immortalized mouse hypothalamic neurons expressing GRH, the...
6.
Zeitler P, Downs T, Frohman L
Endocrinology
. 1993 Dec;
133(6):2782-6.
PMID: 8243305
The homozygous dwarf (dw) rat pituitary is characterized by a 95% reduction in GH content as well as a 75-80% reduction in the number of somatotrophs. The nature of the...
7.
Ahmad I, Finkelstein J, Downs T, Frohman L
Neuroendocrinology
. 1993 Sep;
58(3):332-7.
PMID: 8255393
The secretion of growth hormone (GH) is impaired in the genetically obese Zucker rat where GH gene expression and plasma GH levels are depressed; however, the underlying mechanism of this...
8.
Sato M, Downs T, Frohman L
Peptides
. 1993 Jul;
14(4):671-7.
PMID: 7901844
Signal transduction mechanisms involved in mouse growth hormone-releasing hormone (GRH) and somatostatin (SRIH) release were investigated using an in vitro perifusion system. Hypothalamic fragments were exposed to depolarizing agents, protein...
9.
Zimmerman D, Young Jr W, Ebersold M, Scheithauer B, Kovacs K, Horvath E, et al.
J Clin Endocrinol Metab
. 1993 Jan;
76(1):216-22.
PMID: 8421089
The cause of gigantism in most patients is a GH-secreting pituitary tumor. In this report, a case of congenital gigantism due to probable central hypersection of GH-releasing hormone (GHRH) is...
10.
Friedman A, Ichhpurani A, Moseley W, Alaniz G, Claflin W, Cleary D, et al.
J Med Chem
. 1992 Oct;
35(21):3928-33.
PMID: 1433201
To test the hypothesis that replacing Ala19 in growth hormone-releasing factor (GRF) with more hydrophobic residues will increase growth hormone releasing activity, four GRF analogs were prepared and tested. The...