T R Devereux
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Explore the profile of T R Devereux including associated specialties, affiliations and a list of published articles.
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80
Citations
855
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Recent Articles
11.
Anna C, Sills R, Foley J, Stockton P, Ton T, Devereux T
Cancer Res
. 2000 Jun;
60(11):2864-8.
PMID: 10850429
The molecular pathogenesis of hepatoblastomas in the B6C3F1 mouse is unclear but may involve alterations in the beta-catenin/Wnt signaling pathway as was recently described for chemically induced hepatocellular neoplasms and...
12.
Devereux T, Horikawa I, Anna C, Annab L, Afshari C, Barrett J
Cancer Res
. 2000 Jan;
59(24):6087-90.
PMID: 10626795
The promoter of the hTERT gene encoding the catalytic subunit of telomerase was recently cloned and has a dense CG-rich CpG island, suggesting a role for methylation in regulation of...
13.
Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis
Devereux T, Anna C, Foley J, White C, Sills R, Barrett J
Oncogene
. 1999 Sep;
18(33):4726-33.
PMID: 10467420
beta-catenin activation, and subsequent upregulation of Wnt-signaling, is an important event in the development of certain human and rodent cancers. Recently, mutations in the beta-catenin gene in the region of...
14.
Tam A, Foley J, Devereux T, Maronpot R, Massey T
Cancer Res
. 1999 Aug;
59(15):3634-40.
PMID: 10446974
Inactivation of the p53 tumor suppressor gene is one of the most frequent genetic alterations observed in human lung cancers. However, p53 mutations are more rarely detected in chemically induced...
15.
Sills R, Boorman G, Neal J, Hong H, Devereux T
IARC Sci Publ
. 1999 Jun;
(146):55-86.
PMID: 10353384
Studies of carcinogenesis in rodents are valuable for examining mutagenesis in vivo. An advantage of evaluating the frequency and spectra of ras mutations in chemically induced neoplasms is that the...
16.
Devereux T, Risinger J, Barrett J
IARC Sci Publ
. 1999 Jun;
(146):19-42.
PMID: 10353382
To understand the causes of cancer, it is necessary to elucidate the molecular basis and environmental factors that influence the carcinogenesis process. Cancers are progressive diseases characterized by the accumulation...
17.
Sills R, Hong H, Melnick R, Boorman G, Devereux T
Carcinogenesis
. 1999 May;
20(4):657-62.
PMID: 10223196
Chloroprene is the 2-chloro analog of 1,3-butadiene, a potent carcinogen in laboratory animals. Following 2 years of inhalation exposure to 12.8, 32 or 80 p.p.m. chloroprene, increased incidences of lung...
18.
Festing M, Lin L, Devereux T, Gao F, Yang A, Anna C, et al.
Genomics
. 1998 Oct;
53(2):129-36.
PMID: 9790761
Four putative quantitative trait loci (QTLs) that influence susceptibility to the induction of lung adenomas by urethane in an F2 cross between A/J and BALB/cOlaHsd have been mapped. Following microsatellite...
19.
HONG H, Devereux T, Roycroft J, Boorman G, Sills R
Toxicol Pathol
. 1998 Oct;
26(5):646-50.
PMID: 9789951
Tetrafluoroethylene (TFE) was evaluated for carcinogenicity in inhalation studies because of its high use in the production of Teflon. There was clear evidence of hepatocarcinogenic activity in B6C3F1 mice after...
20.
Lin L, Festing M, Devereux T, Crist K, Christiansen S, Wang Y, et al.
Exp Lung Res
. 1998 Jul;
24(4):481-97.
PMID: 9659579
A locus for mouse pulmonary adenoma susceptibility, Pas-1, has been mapped on distal chromosome 6, where the K-ras gene is located. Allele-specific activation and expression of the K-ras allele from...