T P Makela
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Explore the profile of T P Makela including associated specialties, affiliations and a list of published articles.
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Articles
74
Citations
2038
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Recent Articles
1.
Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja S, Naatsaari L, Karhu A, et al.
Br J Cancer
. 2005 Mar;
92(6):1126-9.
PMID: 15756273
Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins,...
2.
Kaldis P, Ojala P, Tong L, Makela T, Solomon M
Mol Biol Cell
. 2001 Dec;
12(12):3987-99.
PMID: 11739795
In normal cells, activation of cyclin-dependent kinases (cdks) requires binding to a cyclin and phosphorylation by the cdk-activating kinase (CAK). The Kaposi's sarcoma-associated herpesvirus encodes a protein with similarity to...
3.
Ylikorkala A, Rossi D, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, et al.
Science
. 2001 Aug;
293(5533):1323-6.
PMID: 11509733
The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function. Here we show that mice with a targeted disruption of Lkb1 die at midgestation,...
4.
Makiniemi M, Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, et al.
J Biol Chem
. 2001 Jun;
276(32):30399-406.
PMID: 11395493
Topoisomerase IIbeta-binding protein (TopBP1), a human protein with eight BRCT domains, is similar to Saccharomyces cerevisiae Dpb11 and Schizosaccharomyces pombe Cut5 checkpoint proteins and closely related to Drosophila Mus101. We...
5.
Rossi D, Londesborough A, Korsisaari N, Pihlak A, Lehtonen E, Henkemeyer M, et al.
EMBO J
. 2001 Jun;
20(11):2844-56.
PMID: 11387217
The trimeric Cdk7-cyclin H-Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase. Herein we report that...
6.
Luukko K, Ylikorkala A, Makela T
Mech Dev
. 2001 Mar;
101(1-2):209-12.
PMID: 11231077
Transforming growth factor-beta (TGF-beta) signaling is mediated from serine/threonine kinase receptors to transcriptional responses via Smad proteins. Here comparison of mRNA expression of Smad3-7 in mouse embryos (E9-E15) revealed developmentally...
7.
Hermand D, Westerling T, Pihlak A, Thuret J, Vallenius T, Tiainen M, et al.
EMBO J
. 2001 Feb;
20(1-2):82-90.
PMID: 11226158
Activating phosphorylation of cyclin-dependent kinases (Cdks) is mediated by at least two structurally distinct types of Cdk-activating kinases (Caks): the trimeric Cdk7-cyclin H-Mat1 complex in metazoans and the single-subunit Cak1...
8.
Vallenius T, Luukko K, Makela T
J Biol Chem
. 2001 Feb;
275(15):11100-5.
PMID: 10753915
The PDZ-LIM family of proteins (Enigma/LMP-1, ENH, ZASP/Cypher, RIL, ALP, and CLP-36) has been suggested to act as adapters that direct LIM-binding proteins to the cytoskeleton. Most interactions of PDZ-LIM...
9.
Ojala P, Yamamoto K, Castanos-Velez E, Biberfeld P, Korsmeyer S, Makela T
Nat Cell Biol
. 2000 Nov;
2(11):819-25.
PMID: 11056537
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent kinase 6 (CDK6) to form a kinase complex that promotes cell-cycle progression, but can also...
10.
Korsisaari N, Makela T
J Biol Chem
. 2000 Aug;
275(45):34837-40.
PMID: 10958787
Cyclin-dependent kinase 7 (Cdk7) forms a trimeric complex with cyclin H and Mat1 to form the mammalian Cdk-activating kinase, CAK, as well as a part of the basal transcription factor...