T Nicolai Siegel
Overview
Explore the profile of T Nicolai Siegel including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
39
Citations
1402
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Keneskhanova Z, McWilliam K, Cosentino R, Barcons-Simon A, Dobrynin A, Smith J, et al.
Nature
. 2025 Mar;
PMID: 40074895
Antigenic variation is an immune evasion strategy used by many different pathogens. It involves the periodic, non-random switch in the expression of different antigens throughout an infection. How the observed...
2.
Rabuffo C, Schmidt M, Yadav P, Tong P, Carloni R, Barcons-Simon A, et al.
Nat Commun
. 2024 Dec;
15(1):10716.
PMID: 39715762
The eukaryotic nucleus exhibits a highly organized 3D genome architecture, with RNA transcription and processing confined to specific nuclear structures. While intra-chromosomal interactions, such as promoter-enhancer dynamics, are well-studied, the...
3.
Luzak V, Osses E, Danese A, Odendaal C, Cosentino R, Stricker S, et al.
Nucleic Acids Res
. 2024 Dec;
53(3).
PMID: 39673807
Gene expression is a multi-step process that converts DNA-encoded information into proteins, involving RNA transcription, maturation, degradation, and translation. While transcriptional control is a major regulator of protein levels, the...
4.
Beaver A, Keneskhanova Z, Cosentino R, Weiss B, Awuoche E, Smallenberger G, et al.
Nature
. 2024 Nov;
636(8042):E3.
PMID: 39550527
No abstract available.
5.
Beaver A, Keneskhanova Z, Cosentino R, Weiss B, Awuoche E, Smallenberger G, et al.
Nature
. 2024 Oct;
636(8042):430-437.
PMID: 39478231
The protozoan parasite Trypanosoma brucei evades clearance by the host immune system through antigenic variation of its dense variant surface glycoprotein (VSG) coat, periodically 'switching' expression of the VSG using...
6.
Schmidt M, Barcons-Simon A, Rabuffo C, Siegel T
Nucleic Acids Res
. 2024 Jan;
52(5):e23.
PMID: 38281191
Nucleic acid interactome data, such as chromosome conformation capture data and RNA-DNA interactome data, are currently analyzed via pipelines that must be rerun for each new parameter set. A more...
7.
Barcons-Simon A, Carrington M, Siegel T
Nat Microbiol
. 2023 Jul;
8(8):1408-1418.
PMID: 37524976
Antigenic variation as a strategy to evade the host adaptive immune response has evolved in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive, expression of dominant antigens and...
8.
Roson J, Vitarelli M, Costa-Silva H, Pereira K, Pires D, Lopes L, et al.
PLoS Pathog
. 2022 Feb;
18(2):e1009694.
PMID: 35180281
Histone variants play a crucial role in chromatin structure organization and gene expression. Trypanosomatids have an unusual H2B variant (H2B.V) that is known to dimerize with the variant H2A.Z generating...
9.
Cosentino R, Brink B, Siegel T
NAR Genom Bioinform
. 2021 Sep;
3(3):lqab082.
PMID: 34541528
To date, most reference genomes represent a mosaic consensus sequence in which the homologous chromosomes are collapsed into one sequence. This approach produces sequence artefacts and impedes analyses of allele-specific...
10.
Luzak V, Lopez-Escobar L, Siegel T, Figueiredo L
Annu Rev Microbiol
. 2021 Jul;
75:107-128.
PMID: 34228491
Recent developments in single-cell and single-molecule techniques have revealed surprising levels of heterogeneity among isogenic cells. These advances have transformed the study of cell-to-cell heterogeneity into a major area of...