T Nicolai Siegel
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Explore the profile of T Nicolai Siegel including associated specialties, affiliations and a list of published articles.
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39
Citations
1402
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Recent Articles
11.
Faria J, Luzak V, Muller L, Brink B, Hutchinson S, Glover L, et al.
Nat Microbiol
. 2021 Jan;
6(3):289-300.
PMID: 33432154
Highly selective gene expression is a key requirement for antigenic variation in several pathogens, allowing evasion of host immune responses and maintenance of persistent infections. African trypanosomes-parasites that cause lethal...
12.
Kraus A, Vanselow J, Lamer S, Brink B, Schlosser A, Siegel T
Nat Commun
. 2020 Mar;
11(1):1498.
PMID: 32198348
Despite histone H2A variants and acetylation of histones occurring in almost every eukaryotic organism, it has been difficult to establish direct functional links between canonical histones or H2A variant acetylation,...
13.
Kraus A, Brink B, Siegel T
Sci Rep
. 2019 Aug;
9(1):12281.
PMID: 31439880
In most organisms, ribosomal RNA (rRNA) contributes to >85% of total RNA. Thus, to obtain useful information from RNA-sequencing (RNA-seq) analyses at reasonable sequencing depth, typically, mature polyadenylated transcripts are...
14.
Bifeld E, Lorenzen S, Bartsch K, Vasquez J, Siegel T, Clos J
mSystems
. 2018 Dec;
3(6).
PMID: 30505948
The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins. In the protozoan parasite Leishmania donovani,...
15.
Muller L, Cosentino R, Forstner K, Guizetti J, Wedel C, Kaplan N, et al.
Nature
. 2018 Oct;
563(7729):121-125.
PMID: 30333624
Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to evade the immune responses of their hosts. These include antigenic variation, through which an infecting organism prevents clearance by...
16.
Vasquez J, Wedel C, Cosentino R, Siegel T
Nucleic Acids Res
. 2018 Jun;
46(18):e106.
PMID: 29912461
Despite their importance for most DNA-templated processes, the function of individual histone modifications has remained largely unknown because in vivo mutational analyses are lacking. The reason for this is that...
17.
Hassan M, Vasquez J, Guo-Liang C, Meissner M, Siegel T
BMC Genomics
. 2017 Dec;
18(1):961.
PMID: 29228904
Background: The lytic cycle of the protozoan parasite Toxoplasma gondii, which involves a brief sojourn in the extracellular space, is characterized by defined transcriptional profiles. For an obligate intracellular parasite...
18.
GT-rich promoters can drive RNA pol II transcription and deposition of H2A.Z in African trypanosomes
Wedel C, Forstner K, Derr R, Siegel T
EMBO J
. 2017 Jul;
36(17):2581-2594.
PMID: 28701485
Genome-wide transcription studies are revealing an increasing number of "dispersed promoters" that, unlike "focused promoters", lack well-conserved sequence motifs and tight regulation. Dispersed promoters are nevertheless marked by well-defined chromatin...
19.
Wedel C, Siegel T
Exp Parasitol
. 2017 Mar;
180:2-12.
PMID: 28286326
Specific DNA-protein interactions are the basis for many important cellular mechanisms like the regulation of gene expression or replication. Knowledge about the precise genomic locations of DNA-protein interactions is important...
20.
Reynolds D, Hofmeister B, Cliffe L, Siegel T, Anderson B, Beverley S, et al.
Mol Microbiol
. 2016 Apr;
101(4):559-74.
PMID: 27125778
The genomes of kinetoplastids are organized into polycistronic gene clusters that are flanked by the modified DNA base J. Previous work has established a role of base J in promoting...