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T Meinnel

Explore the profile of T Meinnel including associated specialties, affiliations and a list of published articles. Areas
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Articles 44
Citations 939
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Recent Articles
1.
Giglione C, Meinnel T
Expert Opin Ther Targets . 2005 Jul; 5(1):41-57. PMID: 15992167
Peptide deformylases (PDFs) constitute a growing family of hydrolytic enzymes previously believed to be unique to Eubacteria. Recent data from our laboratory have demonstrated that PDF orthologues are present in...
2.
Giglione C, Boularot A, Meinnel T
Cell Mol Life Sci . 2004 Jun; 61(12):1455-74. PMID: 15197470
N-terminal methionine excision (NME) is the major proteolytic pathway responsible for the diversity of N-terminal amino acids in proteins. Dedicated NME components have been identified in all organisms, in all...
3.
Giglione C, Meinnel T
Trends Plant Sci . 2001 Dec; 6(12):566-72. PMID: 11738381
Most mature proteins do not retain their initial N-terminal amino acid (methionine in the cytosol and N-formyl methionine in the organelles). Recent studies have shown that dedicated machinery is involved...
4.
Serero A, Giglione C, Meinnel T
J Mol Biol . 2001 Dec; 314(4):695-708. PMID: 11733990
Peptide deformylases (PDFs) are essential enzymes of the N-terminal protein processing pathway of eubacteria. The recent discovery of two types of PDFs in higher plants, PDF1A and PDF1B, and the...
5.
Giglione C, Serero A, Pierre M, Boisson B, Meinnel T
EMBO J . 2000 Nov; 19(21):5916-29. PMID: 11060042
The N-terminal protein processing pathway is an essential mechanism found in all organisms. However, it is widely believed that deformylase, a key enzyme involved in this process in bacteria, does...
6.
Giglione C, Pierre M, Meinnel T
Mol Microbiol . 2000 Aug; 36(6):1197-205. PMID: 10931273
Peptide deformylase was discovered 30 years ago, but as a result of its unusually unstable activity it was not fully characterized until very recently. The aim of this paper is...
7.
Meinnel T
Parasitol Today . 2000 Mar; 16(4):165-8. PMID: 10725904
Peptide deformylase is found only in Eubacteria, making it a logical target for discovering new antibacterial agents. Although this protein is absent from animal or fungal cells, evidence supports its...
8.
Meinnel T
Pathol Biol (Paris) . 1999 Nov; 47(8):780-3. PMID: 10573696
No abstract available.
9.
Meinnel T, Sacerdot C, Graffe M, Blanquet S, Springer M
J Mol Biol . 1999 Jul; 290(4):825-37. PMID: 10398584
Translation initiation factor IF3, one of three factors specifically required for translation initiation in Escherichia coli, inhibits initiation on any codon other than the three canonical initiation codons, AUG, GUG,...
10.
Ragusa S, Mouchet P, Lazennec C, Dive V, Meinnel T
J Mol Biol . 1999 Jun; 289(5):1445-57. PMID: 10373378
The substrate specificity of Escherichia coli peptide deformylase was investigated by measuring the efficiency of the enzyme to cleave formyl- peptides of the general formula Fo-Xaa-Yaa-NH2, where Xaa represents a...