T M Speight
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Explore the profile of T M Speight including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
2626
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Recent Articles
11.
Richards D, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1984 Mar;
27(3):210-31.
PMID: 6200290
Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those...
12.
Ward A, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1984 Feb;
27(2):95-131.
PMID: 6365507
Ursodeoxycholic acid is the 7 beta-hydroxy epimer of chenodeoxycholic acid and is normally present in only trace amounts in the bile. Oral administration of pharmacological doses markedly decreases biliary cholesterol...
13.
Holmes B, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1984 Jan;
27(1):6-44.
PMID: 6141044
Flunarizine is a 'selective' calcium entry blocker with a similar chemical structure and pharmacological profile to the related compound, cinnarizine. However, in contrast to cinnarizine it has a long plasma...
14.
Ward A, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1983 Dec;
26(6):468-502.
PMID: 6360634
Amrinone is a bipyridine derivative with positive inotropic effects and vasodilatory properties. However, in the clinical setting of congestive heart failure, the relative contribution of these factors remains a matter...
15.
Richards D, Carmine A, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1983 Nov;
26(5):378-438.
PMID: 6315332
Acyclovir (aciclovir) is a nucleoside analogue antiviral drug related to cytarabine, idoxuridine, trifluridine and vidarabine. In common with these earlier antivirals, acyclovir is active against some members of the herpesvirus...
16.
Carmine A, Brogden R, Heel R, Romankiewicz J, Speight T, Avery G
Drugs
. 1983 Oct;
26(4):279-333.
PMID: 6354685
Moxalactam (latamoxef) is a new synthetic oxa-beta-lactam antibiotic administered intravenously or intramuscularly. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, is particularly active...
17.
Holmes B, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1983 Sep;
26(3):212-29.
PMID: 6352237
Guanabenz is an orally active central alpha 2-adrenoceptor agonist. Its antihypertensive action is thought to result from a decrease in sympathetic outflow from the brain to the peripheral circulatory system...
18.
Holmes B, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1983 Aug;
26(2):93-123.
PMID: 6411445
Tocainide is an antiarrhythmic drug structurally related to lignocaine with similar electrophysiological, haemodynamic and antiarrhythmic effects. In contrast to lignocaine (lidocaine) it is well absorbed after oral administration and has...
19.
Ward A, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1983 Jul;
26(1):9-43.
PMID: 6224672
Etretinate (Ro 10-9359) is a new aromatic retinoic acid derivative for the treatment of severe psoriasis and other dyskeratoses. The pharmacological profile of etretinate suggests that it acts by normalizing...
20.
Carmine A, Brogden R, Heel R, Speight T, Avery G
Drugs
. 1983 Mar;
25(3):223-89.
PMID: 6303743
Cefotaxime is a new 'third generation' semisynthetic cephalosporin administered intravenously or intramuscularly. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally...