T M Dexter
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Explore the profile of T M Dexter including associated specialties, affiliations and a list of published articles.
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297
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3363
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Recent Articles
11.
Durig J, Testa N, LORD B, Kasper C, Chang J, Telford N, et al.
Leukemia
. 1999 Dec;
13(12):2012-22.
PMID: 10602423
The clonogenic cells of chronic myeloid leukaemia (CML), unlike normal haemopoietic colony forming cells (CFC), are resistant to the growth inhibitory effects of the chemokine, macrophage inflammatory protein-1alpha (MIP-1alpha). Here,...
12.
Scheller M, Foerster J, Heyworth C, Waring J, Lohler J, Gilmore G, et al.
Blood
. 1999 Nov;
94(11):3764-71.
PMID: 10572090
Mice deficient for the transcription factor, interferon consensus sequence binding protein (ICSBP), are immunodeficient and develop disease symptoms similar to human chronic myeloid leukemia (CML). To elucidate the hematopoietic disorder...
13.
Jelinek J, RAFFERTY J, Cmejla R, Hildinger M, Chinnasamy D, Lashford L, et al.
Gene Ther
. 1999 Sep;
6(8):1489-93.
PMID: 10467374
Following transduction with a retrovirus (SF1MIH) expressing both the multidrug resistance 1 (MDR1) and O6-alkylguanine-DNA-alkyltransferase (ATase) proteins, human erythroleukaemic progenitor (K562) cells were isolated which were resistant to killing by...
14.
Johnson B, John V, Henschler R, Hampson I, Heyworth C, Babichuk C, et al.
Gene
. 1999 Jul;
234(1):101-7.
PMID: 10393244
Cytotoxic T cells and early haemopoietic progenitors share the expression of a number of specific genes. Of these, granzyme B has attracted particular interest because of its role in inducing...
15.
Marshall E, Howell A, Powles R, Hunter M, Edwards M, Wood L, et al.
Eur J Cancer
. 1998 Dec;
34(7):1023-9.
PMID: 9849450
BB-10010 is a genetically engineered variant of human macrophage inflammatory protein-1 alpha (hMIP-1 alpha) with improved pharmaceutical formulation properties. Although initially described as a pro-inflammatory cytokine, it is now recognised...
16.
Chinnasamy N, RAFFERTY J, Hickson I, Lashford L, Longhurst S, Thatcher N, et al.
Gene Ther
. 1998 Sep;
5(6):842-7.
PMID: 9747465
Murine bone marrow cells were transduced ex vivo with a retrovirus encoding an O6-benzylguanine (O6-beG) insensitive, double mutant form of the human DNA repair protein O6-alkylguanine-DNA alkyltransferase (hATPA/GA). In animals...
17.
Hickson I, Fairbairn L, Chinnasamy N, Lashford L, Thatcher N, Margison G, et al.
Gene Ther
. 1998 Sep;
5(6):835-41.
PMID: 9747464
Retroviral transduction was used to introduce cDNAs encoding two mutants of human O6-alkylguanine-DNA alkyltransferase (hAT), one of which (hATPA) is 16 times more resistant to O6-benzylguanine (O6-beG), and the other...
18.
Clemons M, Marshall E, Durig J, Watanabe K, Howell A, Miles D, et al.
Blood
. 1998 Aug;
92(5):1532-40.
PMID: 9716580
BB-10010 is a variant of the human form of macrophage inflammatory protein-1alpha (MIP-1alpha), which has been shown in mice to block the entry of hematopoietic stem cells into S-phase and...
19.
Pearson M, OFarrell A, Dexter T, Whetton A, Owen-Lynch P, Heyworth C
Growth Factors
. 1998 Aug;
15(4):293-306.
PMID: 9714913
Stem Cell Factor (SCF), the ligand for the c-kit proto-oncogene, has been shown to synergistically interact with other cytokines, enhancing the responsiveness of haemopoietic precursors. In this study we have...
20.
Pierce A, Owen-Lynch P, Spooncer E, Dexter T, Whetton A
Oncogene
. 1998 Aug;
17(5):667-72.
PMID: 9704934
Chronic myeloid leukaemia (CML) is a clonal disorder of the pluripotent haemopoietic stem cell, the hallmark of which is the constitutively activated Bcr-Abl protein tyrosine kinase. During the initial chronic...