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T Lengauer

Explore the profile of T Lengauer including associated specialties, affiliations and a list of published articles. Areas
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Articles 37
Citations 1476
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Recent Articles
1.
Beggel B, Munk C, Daumer M, Hauck K, Haussinger D, Lengauer T, et al.
J Viral Hepat . 2013 Dec; 20(12):882-9. PMID: 24304458
Human APOBEC3 (A3) cytosine deaminases are antiviral restriction factors capable of editing the genome the hepatitis B virus (HBV). Despite the importance of the human A3 protein family for the...
2.
Lengauer T
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz . 2013 Oct; 56(11):1489-94. PMID: 24170077
Medicine is experiencing a period of change: Extensive molecular biological data on the patient are increasingly included in diagnosis and treatment. This trend is based on the development of targeted...
3.
Zazzi M, Kaiser R, Sonnerborg A, Struck D, Altmann A, Prosperi M, et al.
HIV Med . 2010 Aug; 12(4):211-8. PMID: 20731728
Objectives: The EuResist expert system is a novel data-driven online system for computing the probability of 8-week success for any given pair of HIV-1 genotype and combination antiretroviral therapy regimen...
4.
Mihm U, Hofmann W, Welsch C, Polta A, Lengauer T, Zeuzem S, et al.
J Viral Hepat . 2009 Sep; 17(3):217-21. PMID: 19758279
The mechanisms of synergy in antiviral activity of interferon-alpha and ribavirin in treating chronic hepatitis C virus (HCV) infection are still unknown. Interferon-alpha indirectly induces cleavage of viral RNA by...
5.
Sierra S, Kaiser R, Thielen A, Lengauer T
Eur J Med Res . 2007 Oct; 12(9):453-62. PMID: 17933727
HIV infects target cells by binding of its envelope gp120 protein to CD4 and a coreceptor on the cell surface. In vivo, the different HIV-strains use either CCR5 or CXCR4...
6.
Welker M, Hofmann W, Welsch C, von Wagner M, Herrmann E, Lengauer T, et al.
J Viral Hepat . 2007 Apr; 14(5):338-49. PMID: 17439523
Chronic hepatitis C is a major cause of liver cirrhosis leading to chronic liver failure and hepatocellular carcinoma. Different hepatitis C virus (HCV) proteins have been associated with resistance to...
7.
Sommer I, Rahnenfuhrer J, Domingues F, de Lichtenberg U, Lengauer T
Bioinformatics . 2004 Jan; 20(5):770-6. PMID: 14751994
Motivation: We introduce a new approach to using the information contained in sequence-to-function prediction data in order to recognize protein template classes, a critical step in predicting protein structure. The...
8.
Crass T, Antes I, Basekow R, Bork P, Buning C, Christensen M, et al.
Bioinformatics . 2004 Jan; 20(2):268-70. PMID: 14734319
Summary: The Helmholtz Network for Bioinformatics (HNB) is a joint venture of eleven German bioinformatics research groups that offers convenient access to numerous bioinformatics resources through a single web portal....
9.
Zien A, Aigner T, Zimmer R, Lengauer T
Bioinformatics . 2001 Jul; 17 Suppl 1:S323-31. PMID: 11473024
Microarrays measure values that are approximately proportional to the numbers of copies of different mRNA molecules in samples. Due to technical difficulties, the constant of proportionality between the measured intensities...
10.
Lengauer T, Zimmer R
Brief Bioinform . 2001 Jul; 1(3):275-88. PMID: 11465038
Along the long path from genomic data to a new drug, the knowledge of three-dimensional protein structure can be of significant help in several places. This paper points out such...