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T L Shirley

Explore the profile of T L Shirley including associated specialties, affiliations and a list of published articles. Areas
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1.
Lewers J, Ceballos-Picot I, Shirley T, Mockel L, Egami K, Jinnah H
Neuroscience . 2008 Mar; 152(3):761-72. PMID: 18313225
A unique sensitivity to specific biochemical processes is responsible for selective vulnerability of midbrain dopamine neurons in several diseases. Prior studies have shown these neurons are susceptible to energy failure...
2.
Lecerf J, Shirley T, Zhu Q, Kazantsev A, Amersdorfer P, Housman D, et al.
Proc Natl Acad Sci U S A . 2001 Apr; 98(8):4764-9. PMID: 11296304
This investigation was pursued to test the use of intracellular antibodies (intrabodies) as a means of blocking the pathogenesis of Huntington's disease (HD). HD is characterized by abnormally elongated polyglutamine...
3.
Manley K, Shirley T, Flaherty L, Messer A
Nat Genet . 1999 Dec; 23(4):471-3. PMID: 10581038
Huntington disease (HD), an autosomal dominant, progressive neurodegenerative disorder, is caused by an expanded CAG repeat sequence leading to an increase in the number of glutamine residues in the encoded...