T L Leto
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Explore the profile of T L Leto including associated specialties, affiliations and a list of published articles.
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60
Citations
2107
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Recent Articles
1.
Boudreau H, Casterline B, Burke D, Leto T
Br J Cancer
. 2014 Apr;
110(10):2569-82.
PMID: 24714748
Background: Transforming growth factor-beta (TGF-β) induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis. Mechanisms involved in TGF-β-mediated EMT and...
2.
Rada B, Gardina P, Myers T, Leto T
Mucosal Immunol
. 2010 Oct;
4(2):158-71.
PMID: 20962773
Despite the long-appreciated in vivo role of the redox-active virulence factor pyocyanin in Pseudomonas airway infections and the importance of airway epithelial cells in combating bacterial pathogens, little is known...
3.
Holloway P, Markello T, Leto T
Biophys J
. 2009 May;
37(1):63-4.
PMID: 19431503
No abstract available.
4.
Liang T, Gao J, Fatemi O, Lavigne M, Leto T, Murphy P
J Immunol
. 2001 Nov;
167(11):6609-14.
PMID: 11714831
Spinorphin is an endogenous heptapeptide (leucylvalylvalyltyrosylprolyltryptophylthreonine), first isolated from bovine spinal cord, whose sequence matches a conserved region of beta-hemoglobin. Also referred to as LVV-hemorphin-4 and a member of the...
5.
Gao Y, Xing J, Streuli M, Leto T, Zheng Y
J Biol Chem
. 2001 Oct;
276(50):47530-41.
PMID: 11595749
Signaling specificity of Rho GTPase pathways is achieved in part by selective interaction between members of the Dbl family guanine nucleotide exchange factors (GEFs) and their Rho GTPase substrates. For...
6.
Lavigne M, Malech H, Holland S, Leto T
Circulation
. 2001 Jul;
104(1):79-84.
PMID: 11435342
Background: Previous investigations provide evidence that an enzyme related to the phagocyte NADPH oxidase produces superoxide in the blood vessel wall. These data, however, are confounded by observations that both...
7.
Pessach I, Leto T, Malech H, Levy R
J Biol Chem
. 2001 Jul;
276(36):33495-503.
PMID: 11432850
We have previously established a model of cytosolic phospholipase A(2) (cPLA(2))-deficient differentiated PLB-985 cells (PLB-D cells) and demonstrated that cPLA(2)-generated arachidonic acid (AA) is essential for NADPH oxidase activation. In...
8.
Tiffany H, Lavigne M, Cui Y, Wang J, Leto T, Gao J, et al.
J Biol Chem
. 2001 Apr;
276(26):23645-52.
PMID: 11316806
Amyloid-beta, the pathologic protein in Alzheimer's disease, induces chemotaxis and production of reactive oxygen species in phagocytic cells, but mechanisms have not been fully defined. Here we provide three lines...
9.
Lavigne M, Malech H, Holland S, Leto T
FASEB J
. 2001 Feb;
15(2):285-7.
PMID: 11156938
An NADPH oxidase is thought to function in microglial cells of the central nervous system. These conclusions are based on pharmacological and immunochemical evidence, although these approaches are indirect and...
10.
Dana R, Eigsti C, Holmes K, Leto T
J Biol Chem
. 2000 Aug;
275(42):32566-71.
PMID: 10931844
In activated neutrophils NADPH oxidase is regulated through various signaling intermediates, including heterotrimeric G proteins, kinases, GTPases, and phospholipases. ADP-ribosylation factor (ARF) describes a family of GTPases associated with phospholipase...