T J Silhavy
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Explore the profile of T J Silhavy including associated specialties, affiliations and a list of published articles.
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Articles
142
Citations
6811
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Recent Articles
1.
Rizzitello A, Harper J, Silhavy T
J Bacteriol
. 2001 Nov;
183(23):6794-800.
PMID: 11698367
The periplasm of Escherichia coli contains many proteins proposed to have redundant functions in protein folding. Using depletion analysis, we directly demonstrated that null mutations in skp and surA, as...
2.
Ruiz N, Peterson C, Silhavy T
J Bacteriol
. 2001 Sep;
183(20):5974-81.
PMID: 11566997
The stationary-phase response exhibited by Escherichia coli upon nutrient starvation is mainly induced by a decrease of the ClpXP-dependent degradation of the alternate primary sigma factor RpoS. Although it is...
3.
Raivio T, Silhavy T
Annu Rev Microbiol
. 2001 Sep;
55:591-624.
PMID: 11544368
Envelope stress responses play important physiological roles in a variety of processes, including protein folding, cell wall biosynthesis, and pathogenesis. Many of these responses are controlled by extracytoplasmic function (ECF)...
4.
Eggert U, Ruiz N, Falcone B, Branstrom A, Goldman R, Silhavy T, et al.
Science
. 2001 Aug;
294(5541):361-4.
PMID: 11520949
Small molecules that affect specific protein functions can be valuable tools for dissecting complex cellular processes. Peptidoglycan synthesis and degradation is a process in bacteria that involves multiple enzymes under...
5.
Langen G, Harper J, Silhavy T, Howard S
J Bacteriol
. 2001 Aug;
183(18):5230-8.
PMID: 11514504
DegP is a periplasmic protease that is a member of both the sigma(E) and Cpx extracytoplasmic stress regulons of Escherichia coli and is essential for viability at temperatures above 42...
6.
Hung D, Raivio T, Jones C, Silhavy T, Hultgren S
EMBO J
. 2001 Apr;
20(7):1508-18.
PMID: 11285215
P pili are important virulence factors in uropathogenic Escherichia coli. The Cpx two-component signal transduction system controls a stress response and is activated by misfolded proteins in the periplasm. We...
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Raivio T, Laird M, Joly J, Silhavy T
Mol Microbiol
. 2000 Sep;
37(5):1186-97.
PMID: 10972835
The Cpx envelope stress response of Escherichia coli is controlled by a two-component regulatory system that senses misfolded proteins in extracytoplasmic compartments and responds by inducing the expression of envelope...
10.
Gibson K, Silhavy T
J Bacteriol
. 2000 Jun;
182(14):4117-20.
PMID: 10869095
SprE regulates sigma(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels...