T J Ahern
Overview
Explore the profile of T J Ahern including associated specialties, affiliations and a list of published articles.
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15
Citations
525
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0
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Recent Articles
1.
Yan H, DeLisser H, Pilewski J, Barone K, Szklut P, Chang X, et al.
J Immunol
. 1994 Mar;
152(6):3053-63.
PMID: 7511636
In order to study the in vivo role of E-selectin in human inflammation, we have developed a model in which human skin is transplanted onto severe combined immunodeficient (SCID) mice....
2.
Sako D, Chang X, Barone K, Vachino G, White H, Shaw G, et al.
Cell
. 1993 Dec;
75(6):1179-86.
PMID: 7505206
The initial adhesive interactions between circulating leukocytes and endothelia are mediated, in part, by P-selectin. We now report the expression cloning of a functional ligand for P-selectin from an HL-60...
3.
Leeuwenberg J, Smeets E, Neefjes J, Shaffer M, Cinek T, Jeunhomme T, et al.
Immunology
. 1992 Dec;
77(4):543-9.
PMID: 1283598
Endothelial cells respond to several cytokines by a rapid increase in expression of the adhesion molecules E-selectin and intercellular adhesion molecule-1 (ICAM-1), followed by a gradual decline. The fate of...
4.
Yuen C, Lawson A, Chai W, Larkin M, Stoll M, Stuart A, et al.
Biochemistry
. 1992 Sep;
31(38):9126-31.
PMID: 1382586
E-selectin is the inducible adhesion protein on the surface of endothelial cells which has a crucial role in the initial stages of recruitment of leucocytes to sites of inflammation. In...
5.
Larkin M, Ahern T, Stoll M, Shaffer M, Sako D, OBrien J, et al.
J Biol Chem
. 1992 Jul;
267(19):13661-8.
PMID: 1377689
Carbohydrate recognition by the human endothelial-leukocyte adhesion molecule, E-selectin, has been investigated by binding studies using 3H-labeled Chinese hamster ovary cells expressing different levels of the transfected full-length adhesion molecule...
6.
Larsen G, Sako D, Ahern T, Shaffer M, Erban J, Sajer S, et al.
J Biol Chem
. 1992 Jun;
267(16):11104-10.
PMID: 1375936
P-selectin on platelets and endothelial cells and E-selectin on endothelial cells are leukocyte receptors that recognize lineage-specific carbohydrates on neutrophils and monocytes. The proposed ligands for these receptors contain the...
7.
Ahern T, Angus L, Barone K, Brenner M, Horgan P, Morris G, et al.
J Biol Chem
. 1991 Feb;
266(6):3715-23.
PMID: 1847387
A novel triple-kringle plasminogen activator protein, PK1 delta FE1X, has been produced which is a genetic chimera between the fibrin binding kringle 1 domain of plasminogen and the two kringles...
8.
Ahern T, Morris G, Barone K, Horgan P, Timony G, Angus L, et al.
J Biol Chem
. 1990 Apr;
265(10):5540-5.
PMID: 2108143
Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo...
9.
Ahern T, Klibanov A
Methods Biochem Anal
. 1988 Jan;
33:91-127.
PMID: 3282153
No abstract available.
10.
Casal J, Ahern T, Davenport R, Petsko G, Klibanov A
Biochemistry
. 1987 Mar;
26(5):1258-64.
PMID: 3552044
We have replaced asparagine residues at the subunit interface of yeast triosephosphate isomerase (TIM) using site-directed mutagenesis in order to elucidate the effects of substitutions on the catalytic activity and...