T H M Ottenhoff
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Explore the profile of T H M Ottenhoff including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
729
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Recent Articles
1.
Szachniewicz M, van den Eeden S, van Meijgaarden K, Franken K, van Veen S, Geluk A, et al.
Eur J Pharm Sci
. 2024 Dec;
205():106995.
PMID: 39710106
Tuberculosis (TB) remains a significant global health challenge, latently affecting around a quarter of the global population. The sole licensed TB vaccine, Mycobacterium bovis Bacillus Calmette-Guérin (BCG), shows variable efficacy,...
2.
Szachniewicz M, van Meijgaarden K, Kavrik E, Jiskoot W, Bouwstra J, Haks M, et al.
Int Immunopharmacol
. 2024 Dec;
145:113782.
PMID: 39647287
Tuberculosis (TB) is a major global health problem, and the development of effective and safe vaccines is urgently needed. CD8 T-cells play an important role alongside CD4 T-cells in the...
3.
Szachniewicz M, van den Eeden S, van Meijgaarden K, Franken K, van Veen S, Geluk A, et al.
Eur J Pharm Biopharm
. 2024 Aug;
203:114437.
PMID: 39122053
Tuberculosis (TB) has been and still is a global emergency for centuries. Prevention of disease through vaccination would have a major impact on disease prevalence, but the only available current...
4.
Szachniewicz M, Neustrup M, van Meijgaarden K, Jiskoot W, Bouwstra J, Haks M, et al.
Eur J Pharm Sci
. 2024 Feb;
195:106730.
PMID: 38382622
Tuberculosis (TB) is still among the deadliest infectious diseases, hence there is a pressing need for more effective TB vaccines. Cationic liposome subunit vaccines are excellent vaccine candidates offering effective...
5.
Biesbroek G, Kapitein B, Kuipers I, Gruppen M, van Stijn D, Peros T, et al.
PLoS One
. 2022 Nov;
17(11):e0266336.
PMID: 36449533
Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki...
6.
Heemskerk M, Korbee C, Esselink J, Dos Santos C, van Veen S, Gordijn I, et al.
Sci Rep
. 2021 Oct;
11(1):19634.
PMID: 34608194
The persistent increase of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) infections negatively impacts Tuberculosis treatment outcomes. Host-directed therapies (HDT) pose an complementing strategy, particularly since Mtb is highly successful in evading...
7.
Ottenhoff T
Ned Tijdschr Geneeskd
. 2020 Sep;
164.
PMID: 32940985
In the past 2 years, research on new tuberculosis vaccines and correlates of immunity against tuberculosis has led to significant breakthroughs. This gives real hope for the development and evaluation...
8.
van Loon W, Gomez M, Jobe D, Franken K, Ottenhoff T, Coninx M, et al.
BMC Infect Dis
. 2020 Jul;
20(1):469.
PMID: 32615981
Background: Interferon-γ release assays (IGRA) with Resuscitation promoting factor (Rpf) proteins enhanced tuberculosis (TB) screening and diagnosis in adults but have not been evaluated in children. Children often develop paucibacillary...
9.
Sutherland J, Loxton A, Haks M, Kassa D, Ambrose L, Lee J, et al.
Clin Microbiol Infect
. 2013 Nov;
20(4):O230-8.
PMID: 24205913
New diagnostics and vaccines for tuberculosis (TB) are urgently needed, but require an understanding of the requirements for protection from/susceptibility to TB. Previous studies have used unbiased approaches to determine...
10.
Legesse M, Ameni G, Medhin G, Mamo G, Franken K, Ottenhoff T, et al.
Scand J Immunol
. 2013 May;
78(3):266-74.
PMID: 23713613
Little attention has been given to the role of antibodies against Mycobacterium tuberculosis (Mtb) infection. We have compared the levels of IgA and IgG against ESAT-6/CFP-10 and Rv2031c antigens in...