T H M Ottenhoff
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Explore the profile of T H M Ottenhoff including associated specialties, affiliations and a list of published articles.
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31
Citations
729
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Recent Articles
11.
Ottenhoff T
Int J Tuberc Lung Dis
. 2012 Oct;
16(11):1424-32.
PMID: 23044443
In this review, we discuss the 'knowns' and 'unknowns' of host defence towards Mycobacterium tuberculosis. With regard to the 'knowns', both protective and immunopathogenic mechanisms are discussed, including recently discovered...
12.
Britten C, Janetzki S, Butterfield L, Ferrari G, Gouttefangeas C, Huber C, et al.
Immunity
. 2012 Jul;
37(1):1-2.
PMID: 22840835
No abstract available.
13.
de Steenwinkel J, de Knegt G, ten Kate M, Verbrugh H, Ottenhoff T, Bakker-Woudenberg I
Eur J Clin Microbiol Infect Dis
. 2011 Oct;
31(6):1195-201.
PMID: 21983896
There are limitations on diagnostic methods to differentiate between active and latent tuberculosis (TB), and the prediction of latent progression to TB disease is yet complex. Traditionally, tuberculosis-specific host immune...
14.
Joosten S, Goeman J, Sutherland J, Opmeer L, de Boer K, Jacobsen M, et al.
Genes Immun
. 2011 Sep;
13(1):71-82.
PMID: 21956656
Owing to our lack of understanding of the factors that constitute protective immunity during natural infection with Mycobacterium tuberculosis (Mtb), there is an urgent need to identify host biomarkers that...
15.
Romano M, Aryan E, Korf H, Bruffaerts N, Franken C, Ottenhoff T, et al.
Microbes Infect
. 2011 Sep;
14(1):86-95.
PMID: 21920450
Novel vaccines are needed to control tuberculosis (TB), the bacterial infectious disease that together with malaria and HIV is worldwide responsible for high levels of morbidity and mortality. TB can...
16.
Parsons S, Warren R, Ottenhoff T, Gey van Pittius N, Van Helden P
Res Vet Sci
. 2011 Apr;
92(3):414-9.
PMID: 21507442
Dogs infected with Mycobacterium tuberculosis can develop clinical tuberculosis (TB) but there are currently no validated immunological assays for diagnosing this infection in this species. Using a post mortem survey...
17.
van de Vosse E, Ottenhoff T, de Paus R, Verhard E, de Boer T, van Dissel J, et al.
Infection
. 2010 Mar;
38(2):128-30.
PMID: 20213287
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare disorder with predisposition to severe, sometimes lethal, disease caused by otherwise poorly virulent, non-tuberculous environmental mycobacteria and poorly virulent salmonellae. In...
18.
Goletti D, Butera O, Vanini V, Lauria F, Lange C, Franken K, et al.
Eur Respir J
. 2009 Nov;
36(1):135-42.
PMID: 19926735
Interferon-gamma release assays based on region of difference 1 antigens have improved diagnosis of latent tuberculosis infection (LTBI). However, these tests cannot discriminate between recently acquired infection (higher risk of...
19.
Stalenhoef J, Alisjahbana B, Nelwan E, van der Ven-Jongekrijg J, Ottenhoff T, van der Meer J, et al.
Eur J Clin Microbiol Infect Dis
. 2007 Oct;
27(2):97-103.
PMID: 17962984
As patients with diabetes mellitus are at increased risk of developing tuberculosis, we hypothesized that this susceptibility to mycobacterial infection is due to a defective Th1-cytokine response. To explore this...
20.
Sahiratmadja E, Alisjahbana B, Buccheri S, Di Liberto D, de Boer T, Adnan I, et al.
Tuberculosis (Edinb)
. 2007 Mar;
87(4):312-21.
PMID: 17382591
Granulysin is a recently identified cytolytic protein which is expressed by human cytotoxic T-lymphocytes and natural killer (NK)-cells, and has broad antimicrobial and tumoricidal activity. Circulating granulysin levels are associated...