T E Smithgall
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Explore the profile of T E Smithgall including associated specialties, affiliations and a list of published articles.
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58
Citations
1040
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Recent Articles
1.
Pene-Dumitrescu T, Peterson L, Donato N, Smithgall T
Oncogene
. 2008 Sep;
27(56):7055-69.
PMID: 18794796
Chronic myelogenous leukemia (CML) is driven by Bcr-Abl, a constitutively active protein-tyrosine kinase that stimulates proliferation and survival of myeloid progenitors. Global inhibition of myeloid Src family kinase (SFK) activity...
2.
Engen J, Wales T, Hochrein J, Meyn 3rd M, Ozkan S, Bahar I, et al.
Cell Mol Life Sci
. 2008 Jun;
65(19):3058-73.
PMID: 18563293
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src family share the same domain organization, with modular SH3, SH2 and...
3.
Pecquet C, Nyga R, Penard-Lacronique V, Smithgall T, Murakami H, Regnier A, et al.
Oncogene
. 2006 Sep;
26(11):1577-85.
PMID: 16953222
Tel-Abl and Tel-Jak2 are fusion proteins associated with human haematologic neoplasms. They possess constitutive tyrosine kinase activity and activate common downstream signalling pathways like Stat-5, PI3-K/Akt, Ras/MapK and NF-kappaB. In...
4.
Gmeiner W, Xu I, Horita D, Smithgall T, Engen J, Smith D, et al.
Cell Biochem Biophys
. 2002 Mar;
35(2):115-26.
PMID: 11892787
SH3 domains are a conserved feature of many nonreceptor protein tyrosine kinases, such as Hck, and often function in substrate recruitment and regulation of kinase activity. SH3 domains modulate kinase...
5.
Xie S, Wang Y, Liu J, Sun T, Wilson M, Smithgall T, et al.
Oncogene
. 2001 Oct;
20(43):6188-95.
PMID: 11593427
We have previously reported that the Jak2 tyrosine kinase but not Jak1 is tyrosine phosphorylated in the absence of IL-3 in Bcr-Abl positive M3.16 cells, which are rendered IL-3 independent...
6.
Cheng H, Schiavone A, Smithgall T
Mol Cell Biol
. 2001 Aug;
21(18):6170-80.
PMID: 11509660
The c-fes locus encodes a 93-kDa non-receptor protein tyrosine kinase (Fes) that regulates the growth and differentiation of hematopoietic and vascular endothelial cells. Unique to Fes is a long N-terminal...
7.
Briggs S, Scholtz B, Jacque J, Swingler S, Stevenson M, Smithgall T
J Biol Chem
. 2001 May;
276(27):25605-11.
PMID: 11328823
Human immunodeficiency virus Nef is a small myristylated protein that plays a critical role in AIDS progression. Nef binds with high affinity to the SH3 domain of the myeloid-restricted tyrosine...
8.
Rogers J, Cheng H, Smithgall T
Cell Growth Differ
. 2000 Nov;
11(11):581-92.
PMID: 11095247
The c-fes proto-oncogene encodes a Mr 93,000 protein-tyrosine kinase (Fes) that is strongly expressed in myeloid cells and has been implicated in myelomonocytic differentiation. Fes autophosphorylation and transforming activity are...
9.
Smithgall T, Briggs S, Schreiner S, Lerner E, Cheng H, Wilson M
Oncogene
. 2000 Jun;
19(21):2612-8.
PMID: 10851060
Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on...
10.
Lionberger J, Wilson M, Smithgall T
J Biol Chem
. 2000 Jun;
275(24):18581-5.
PMID: 10849448
Bcr-Abl is the constitutively active protein-tyrosine kinase expressed as a result of the Philadelphia translocation in chronic myelogenous leukemia. Bcr-Abl is coupled to many of the same signaling pathways normally...