T D Geppert
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Explore the profile of T D Geppert including associated specialties, affiliations and a list of published articles.
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36
Citations
861
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Recent Articles
1.
The cytoplasmic and the transmembrane domains are not sufficient for class I MHC signal transduction
Gur H, Geppert T, Wacholtz M, Lipsky P
Cell Immunol
. 1999 Feb;
191(2):105-16.
PMID: 9973532
Class I MHC molecules deliver activation signals to T cells. To analyze the role of the cytoplasmic and the transmembrane (TM) domains of class I MHC molecules in T cell...
2.
Swantek J, Cobb M, Geppert T
Mol Cell Biol
. 1997 Oct;
17(11):6274-82.
PMID: 9343388
The adverse effects of lipopolysaccharide (LPS) are mediated primarily by tumor necrosis factor alpha (TNF-alpha). TNF-alpha production by LPS-stimulated macrophages is regulated at the levels of both transcription and translation....
3.
Gur H, Geppert T, Lipsky P
Mol Immunol
. 1997 Feb;
34(2):125-32.
PMID: 9188845
The role of the cytoplasmic domain in a variety of the functional activities of class I MHC molecules has not been documented. To address this question, Jurkat cells were transfected...
4.
Whitehurst C, Geppert T
J Immunol
. 1996 Feb;
156(3):1020-9.
PMID: 8557975
TCR engagement stimulates the activation of the protein kinase Raf-1. Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase 1 (MEK1), which in turn phosphorylates and...
5.
Whitehurst C, Owaki H, Bruder J, Rapp U, Geppert T
J Biol Chem
. 1995 Mar;
270(10):5594-9.
PMID: 7534298
Deletion of the amino-terminal domain of Raf-1, which contains the Ras-binding region, results in the constitutive activation of the liberated Raf-1 catalytic domain in fibroblast cell lines. We demonstrate that...
6.
Geppert T, Whitehurst C, Thompson P, Beutler B
Mol Med
. 1994 Nov;
1(1):93-103.
PMID: 8790605
Background: Lipopolysaccharide (LPS) is known to activate macrophages, causing the release of toxic cytokines that may provoke inflammation and shock. One of the most important and best studied of these...
7.
Frost J, Geppert T, Cobb M, Feramisco J
Proc Natl Acad Sci U S A
. 1994 Apr;
91(9):3844-8.
PMID: 8170999
The role of ERK-1 and ERK-2 in wild-type (wt) Ha-Ras, phorbol 12-myristate 13-acetate (PMA), and serum-induced AP-1 activity was studied. Microinjection of ERK-specific substrate peptides inhibited the induction of AP-1...
8.
Owaki H, Varma R, Gillis B, Bruder J, Rapp U, Davis L, et al.
EMBO J
. 1993 Nov;
12(11):4367-73.
PMID: 8223446
Engagement of the T cell receptor/CD3 complex activates the serine/threonine kinase, Raf-1, but the physiologic consequences of its activation have not been determined. The effects of Raf-1 on interleukin 2...
9.
Robbins D, Zhen E, Owaki H, Vanderbilt C, Ebert D, Geppert T, et al.
J Biol Chem
. 1993 Mar;
268(7):5097-106.
PMID: 8444886
Extracellular signal-regulated protein kinases (ERK) 1 and 2 and mutants of each were expressed in bacteria with a hexahistidine tag and purified using nickel-chelate chromatography. Basal activity of wild type...
10.
Gur H, Wacholtz M, Lie W, Lipsky P, Geppert T
Cell Immunol
. 1992 Oct;
144(2):392-406.
PMID: 1394450
The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine...