T C Spelsberg
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Explore the profile of T C Spelsberg including associated specialties, affiliations and a list of published articles.
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216
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3406
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Recent Articles
11.
Rickard D, Monroe D, Ruesink T, Khosla S, Riggs B, Spelsberg T
J Cell Biochem
. 2003 May;
89(3):633-46.
PMID: 12761896
Genistein, a soybean isoflavone, has estrogen-like activity in mammals, including the prevention of bone loss. However, whether its mechanism of action on bone turnover is distinct from that of estrogen...
12.
Monroe D, Johnsen S, Subramaniam M, Getz B, Khosla S, Riggs B, et al.
J Endocrinol
. 2003 Mar;
176(3):349-57.
PMID: 12630920
Estrogen is a major sex steroid that affects the growth, maintenance, and homeostasis of the skeleton. Two isoforms of the estrogen receptor (ERalpha and ERbeta) mediate the transcriptional effects of...
13.
Monroe D, Spelsberg T
Calcif Tissue Int
. 2003 Jan;
72(3):183-4.
PMID: 12522664
No abstract available.
14.
Maran A, Zhang M, Kennedy A, Sibonga J, Rickard D, Spelsberg T, et al.
Bone
. 2002 Feb;
30(2):393-8.
PMID: 11856647
2-Methoxyestradiol (2-ME), a naturally occurring mammalian metabolite of 17beta-estradiol, has been implicated as a physiological inhibitor of tumor cell proliferation. In this study, the effects of 2-ME on cultured osteosarcomatous...
15.
Gebhart J, Rickard D, Barrett T, Lesnick T, Webb M, Podratz K, et al.
Am J Obstet Gynecol
. 2001 Dec;
185(6):1325-30; discussion 1330-1.
PMID: 11744904
Objective: To determine the messenger RNA expression patterns of estrogen receptor (ER)alpha and ER beta in human vaginal tissue. Study Design: Reverse transcriptase-polymerase chain reaction was performed on tissue samples...
16.
Waters K, Rickard D, Riggs B, Khosla S, Katzenellenbogen J, Katzenellenbogen B, et al.
J Cell Biochem
. 2001 Oct;
83(3):448-62.
PMID: 11596113
Although osteoblasts have been shown to respond to estrogens and express both isoforms of the estrogen receptor (ER alpha and ER beta), the role each isoform plays in osteoblast cell...
17.
Maran A, Zhang M, Spelsberg T, Turner R
J Bone Miner Res
. 2001 Feb;
16(2):270-6.
PMID: 11204427
Alcohol is a risk factor for the development of osteoporosis, especially in men. Chronic alcohol abuse decreases bone mass, which contributes to the increased incidence of fractures. To better understand...
18.
Hofbauer L, Shui C, Riggs B, Dunstan C, Spelsberg T, OBrien T, et al.
Biochem Biophys Res Commun
. 2001 Feb;
280(1):334-9.
PMID: 11162519
Osteoporosis and vasculopathy are common after organ transplantation and have been largely attributed to the use of immunosuppressants. Osteoprotegerin (OPG) is produced by osteoblastic and arterial cells, and inhibits osteoclast...
19.
Gori F, Hofbauer L, Dunstan C, Spelsberg T, Khosla S, Riggs B
Endocrinology
. 2000 Dec;
141(12):4768-76.
PMID: 11108292
The one or more molecular mechanisms that determine the obligatory sequence of resorption followed by formation during bone remodeling is unclear. RANK ligand (RANK-L) is an essential requirement for osteoclastogenesis,...
20.
Reinholz G, Getz B, Pederson L, Sanders E, Subramaniam M, Ingle J, et al.
Cancer Res
. 2000 Nov;
60(21):6001-7.
PMID: 11085520
Bisphosphonates are widely used clinically to treat bone diseases in which bone resorption is in excess. However, the mechanism of bisphosphonate action on bone is not fully understood. Studies of...