T C Nichols
Overview
Explore the profile of T C Nichols including associated specialties, affiliations and a list of published articles.
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54
Citations
800
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Recent Articles
1.
Maile L, Busby W, Xi G, Gollahan K, Flowers W, Gafbacik N, et al.
Atherosclerosis
. 2017 Feb;
258:40-50.
PMID: 28189040
Background And Aims: Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (VSMC) to secrete ligands that bind to the αVβ3 integrin,...
2.
Nichols T, Hough C, Agerso H, Ezban M, Lillicrap D
J Thromb Haemost
. 2016 Mar;
14(5):894-905.
PMID: 26924758
Animal models of inherited bleeding disorders are important for understanding disease pathophysiology and are required for preclinical assessment of safety prior to testing of novel therapeutics in human and veterinary...
3.
Agerso H, Stennicke H, Pelzer H, Olsen E, Merricks E, Defriess N, et al.
Haemophilia
. 2012 Jul;
18(6):941-7.
PMID: 22812621
The objective of the present study was to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of the new recombinant FVIII compound turoctocog alfa and a Glyco-PEGylated FVIII derivative thereof...
4.
Nolte M, Nichols T, Mueller-Cohrs J, Merricks E, Pragst I, Zollner S, et al.
J Thromb Haemost
. 2012 Jun;
10(8):1591-9.
PMID: 22726310
Background: Prophylaxis of hemophilia B, at present, requires multiple infusions of human factor (F)IX concentrates per week. A FIX molecule with a prolonged half-life has the potential to greatly improve...
5.
Nichols T, Franck H, Franck C, De Friess N, Raymer R, Merricks E
J Thromb Haemost
. 2012 Apr;
10(3):474-6.
PMID: 22482117
No abstract available.
6.
Karpf D, Kjalke M, Thim L, Agerso H, Merricks E, Defriess N, et al.
Haemophilia
. 2011 Jun;
17(5):e963-8.
PMID: 21682818
N8, a new recombinant factor VIII (rFVIII) compound developed for the treatment of haemophilia A, is produced in Chinese hamster ovary (CHO) cells and formulated without human- or animal-derived materials....
7.
Knudsen T, Kristensen A, Nichols T, Agerso H, Jensen A, Kjalke M, et al.
Haemophilia
. 2011 Jun;
17(6):962-70.
PMID: 21645178
Recombinant human FVIIa (rhFVIIa) corrects the coagulopathy in hemophilia A and B as well as FVII deficiency. This is also the case in dogs until canine anti-human FVIIa antibodies develop...
8.
Nichols T, Raymer R, Franck H, Merricks E, Bellinger D, Defriess N, et al.
Haemophilia
. 2010 Jul;
16 Suppl 3:19-23.
PMID: 20586797
Dogs with haemophilia A or haemophilia B exhibit spontaneous bleeding comparable with the spontaneous bleeding phenotype that occurs in humans with severe haemophilia. The phenotypic and genotypic characteristics of haemophilic...
9.
Ragni M, Jankowitz R, CHAPMAN H, Merricks E, Kloos M, Dillow A, et al.
Haemophilia
. 2008 Aug;
14(5):968-77.
PMID: 18680527
von Willebrand factor (VWF) is a multimeric glycoprotein that mediates platelet adhesion and is decreased in von Willebrand disease (VWD). 1-8 deamino-d-arginine vasopressin (DDAVP), the most common treatment for VWD,...
10.
Nichols T, Busby Jr W, Merricks E, Sipos J, Rowland M, Sitko K, et al.
Endocrinology
. 2007 Jul;
148(10):5002-10.
PMID: 17640990
IGF-I has been shown to play a role in the progression of atherosclerosis in experimental animal models. IGF-binding protein-4 (IGFBP-4) binds to IGF-I and prevents its association with receptors. Overexpression...