T C Appleby
Overview
Explore the profile of T C Appleby including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
135
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Recent Articles
1.
Appleby T, Mathews I, Porcelli M, Cacciapuoti G, Ealick S
J Biol Chem
. 2001 Aug;
276(42):39232-42.
PMID: 11489901
The structure of 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus (SsMTAP) has been determined alone, as ternary complexes with sulfate plus substrates 5'-deoxy-5'-methylthioadenosine, adenosine, or guanosine, or with the noncleavable substrate analog...
2.
Begley T, Appleby T, Ealick S
Curr Opin Struct Biol
. 2000 Dec;
10(6):711-8.
PMID: 11114509
The three-dimensional structures of orotidine 5'-monophosphate decarboxylases from four different organisms have been determined by X-ray crystallography. The structures reveal an active site in which the pyrimidine base and phosphate...
3.
Appleby T, Kinsland C, Begley T, Ealick S
Proc Natl Acad Sci U S A
. 2000 Feb;
97(5):2005-10.
PMID: 10681442
The crystal structure of Bacillus subtilis orotidine 5'-monophosphate (OMP) decarboxylase with bound uridine 5'-monophosphate has been determined by multiple wavelength anomalous diffraction phasing techniques and refined to an R-factor of...
4.
Appleby T, Erion M, Ealick S
Structure
. 1999 Jul;
7(6):629-41.
PMID: 10404592
Background: 5'-Deoxy-5'-methylthioadenosine phosphorylase (MTAP) catalyzes the reversible phosphorolysis of 5'-deoxy-5'-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1-phosphate. MTA is a by-product of polyamine biosynthesis, which is essential for cell growth and proliferation....
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Edwards Jr W, Kaiser A, Kernodle D, Appleby T, Edwards Sr W, Martin 3rd R, et al.
J Vasc Surg
. 1992 Jan;
15(1):35-41; discussion 41-2.
PMID: 1728688
Although cefazolin prophylaxis has proven efficacy in vascular surgery, Staphylococcus aureus wound infections are still an important postoperative complication. In cardiac surgery, cefazolin's susceptibility to hydrolysis by staphylococcal beta-lactamase has...