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T A Willson

Explore the profile of T A Willson including associated specialties, affiliations and a list of published articles. Areas
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Articles 37
Citations 2761
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Recent Articles
1.
Witkowski M, Cimmino L, Hu Y, Trimarchi T, Tagoh H, McKenzie M, et al.
Leukemia . 2015 Feb; 29(6):1301-11. PMID: 25655195
Activating NOTCH1 mutations occur in ~60% of human T-cell acute lymphoblastic leukemias (T-ALLs), and mutations disrupting the transcription factor IKZF1 (IKAROS) occur in ~5% of cases. To investigate the regulatory...
2.
Zhang J, Metcalf D, Rakar S, Asimakis M, Greenhalgh C, Willson T, et al.
Proc Natl Acad Sci U S A . 2001 Oct; 98(23):13261-5. PMID: 11606785
Suppressor of Cytokine Signaling-1 (SOCS-1) is an essential physiological inhibitor of IFN-gamma signaling. Mice lacking this gene die in the early postnatal period from a disease characterized by hyperresponsiveness to...
3.
Nicola N, Nicholson S, Metcalf D, Zhang J, Baca M, Farley A, et al.
Cold Spring Harb Symp Quant Biol . 2001 Mar; 64:397-404. PMID: 11232314
No abstract available.
4.
Kile B, Viney E, Willson T, Brodnicki T, Cancilla M, Herlihy A, et al.
Gene . 2000 Dec; 258(1-2):31-41. PMID: 11111040
Members of the suppressor of cytokine signalling (SOCS) family of proteins have been shown to inhibit cytokine signalling via direct interactions with JAK kinases or activated cytokine receptors. In addition...
5.
Metcalf D, Greenhalgh C, Viney E, Willson T, Starr R, Nicola N, et al.
Nature . 2000 Jul; 405(6790):1069-73. PMID: 10890450
Suppressor of cytokine signalling-2 (SOCS-2) is a member of the suppressor of cytokine signalling family, a group of related proteins implicated in the negative regulation of cytokine action through inhibition...
6.
Nicholson S, De Souza D, Fabri L, Corbin J, Willson T, Zhang J, et al.
Proc Natl Acad Sci U S A . 2000 Jun; 97(12):6493-8. PMID: 10829066
Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit gp130. The...
7.
Alexander W, Starr R, Metcalf D, Nicholson S, Farley A, Elefanty A, et al.
J Leukoc Biol . 1999 Oct; 66(4):588-92. PMID: 10534114
SOCS-1 was originally identified as an inhibitor of interleukin-6 signal transduction and is a member of a family of proteins (SOCS-1 to SOCS-7 and CIS) that contain an SH2 domain...
8.
Alexander W, Rakar S, Robb L, Farley A, Willson T, Zhang J, et al.
Curr Biol . 1999 Jun; 9(11):605-8. PMID: 10359701
Cytokines control a variety of cellular responses including proliferation, differentiation, survival and functional activation, via binding to specific receptors expressed on the surface of target cells [1]. The cytokine receptors...
9.
Zhang J, Farley A, Nicholson S, Willson T, Zugaro L, Simpson R, et al.
Proc Natl Acad Sci U S A . 1999 Mar; 96(5):2071-6. PMID: 10051596
The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of the Janus kinase/signal...
10.
Nicholson S, Willson T, Farley A, Starr R, Zhang J, Baca M, et al.
EMBO J . 1999 Jan; 18(2):375-85. PMID: 9889194
SOCS-1 (suppressor of cytokine signaling-1) is a representative of a family of negative regulators of cytokine signaling (SOCS-1 to SOCS-7 and CIS) characterized by a highly conserved C-terminal SOCS box...