T A Rapoport
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Explore the profile of T A Rapoport including associated specialties, affiliations and a list of published articles.
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6491
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Recent Articles
11.
Heinrich S, Mothes W, Brunner J, Rapoport T
Cell
. 2000 Aug;
102(2):233-44.
PMID: 10943843
We have investigated how the transmembrane (TM) domain of a membrane protein is cotranslationally integrated into the endoplasmic reticulum. We demonstrate that the Sec61p channel allows the TM domain to...
12.
Prinz W, Grzyb L, Veenhuis M, Kahana J, Silver P, Rapoport T
J Cell Biol
. 2000 Aug;
150(3):461-74.
PMID: 10931860
We find that the peripheral ER in Saccharomyces cerevisiae forms a dynamic network of interconnecting membrane tubules throughout the cell cycle, similar to the ER in higher eukaryotes. Maintenance of...
13.
Morgan D, Menetret J, Radermacher M, Neuhof A, Akey I, Rapoport T, et al.
J Mol Biol
. 2000 Aug;
301(2):301-21.
PMID: 10926511
Protein synthesis in eukaryotes is mediated by both cytoplasmic and membrane-bound ribosomes. During the co-translational translocation of secretory and membrane proteins, eukaryotic ribosomes dock with the protein conducting channel of...
14.
Prinz A, Behrens C, Rapoport T, Hartmann E, Kalies K
EMBO J
. 2000 Apr;
19(8):1900-6.
PMID: 10775273
During early stages of cotranslational protein translocation across the endoplasmic reticulum (ER) membrane the ribosome is targeted to the heterotrimeric Sec61p complex, the major component of the protein-conducting channel. We...
15.
Dreier L, Rapoport T
J Cell Biol
. 2000 Mar;
148(5):883-98.
PMID: 10704440
We have established an in vitro system for the formation of the endoplasmic reticulum (ER). Starting from small membrane vesicles prepared from Xenopus laevis eggs, an elaborate network of membrane...
16.
Rapoport T, Matlack K, Plath K, Misselwitz B, Staeck O
Biol Chem
. 1999 Dec;
380(10):1143-50.
PMID: 10595576
Posttranslational protein translocation across the membrane of the endoplasmic reticulum is mediated by the Sec complex. This complex includes a transmembrane channel formed by multiple copies of the Sec61 protein....
17.
Shamu C, Story C, Rapoport T, Ploegh H
J Cell Biol
. 1999 Oct;
147(1):45-58.
PMID: 10508854
The human cytomegalovirus protein, US11, initiates the destruction of MHC class I heavy chains by targeting them for dislocation from the ER to the cytosol and subsequent degradation by the...
18.
Schroder K, Martoglio B, Hofmann M, Holscher C, Hartmann E, Prehn S, et al.
EMBO J
. 1999 Sep;
18(17):4804-15.
PMID: 10469658
Protein translocation across the membrane of the endoplasmic reticulum (ER) proceeds through a proteinaceous translocation machinery, the translocon. To identify components that may regulate translocation by interacting with nascent polypeptides...
19.
Rolls M, Stein P, Taylor S, Ha E, McKeon F, Rapoport T
J Cell Biol
. 1999 Jul;
146(1):29-44.
PMID: 10402458
The nuclear envelope (NE) is a distinct subdomain of the ER, but few membrane components have been described that are specific to it. We performed a visual screen in tissue...
20.
Misselwitz B, Staeck O, Matlack K, Rapoport T
J Biol Chem
. 1999 Jul;
274(29):20110-5.
PMID: 10400622
Proteins of the Hsp70 family of ATPases interact with a conserved domain of their J-protein partners, the J-domain, to function in numerous cellular processes. We have studied the interaction of...