Sylvie van Twest
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Explore the profile of Sylvie van Twest including associated specialties, affiliations and a list of published articles.
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10
Citations
217
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Recent Articles
1.
Abbouche L, Murphy V, Gao J, van Twest S, Sobinoff A, Auweiler K, et al.
Nucleic Acids Res
. 2024 Aug;
52(18):11029-11044.
PMID: 39189453
FANCM is a DNA repair protein that recognizes stalled replication forks, and recruits downstream repair factors. FANCM activity is also essential for the survival of cancer cells that utilize the...
2.
Hodson C, van Twest S, Dylewska M, ORourke J, Tan W, Murphy V, et al.
Cell Rep
. 2022 Dec;
41(10):111749.
PMID: 36476850
Co-transcriptional R loops arise from stalling of RNA polymerase, leading to the formation of stable DNA:RNA hybrids. Unresolved R loops promote genome instability but are counteracted by helicases and nucleases....
3.
Hodson C, Low J, van Twest S, Jones S, Swuec P, Murphy V, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(6).
PMID: 35115399
The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a heterotetrameric complex (the "Bloom syndrome complex") for dissolution of double Holliday junctions, key intermediates in homologous recombination....
4.
Sharp M, Murphy V, van Twest S, Tan W, Lui J, Simpson K, et al.
Sci Rep
. 2020 May;
10(1):7959.
PMID: 32409752
DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription. ICLs can be caused by endogenous reactive metabolites or from chemotherapeutics. ICL repair...
5.
Tan W, van Twest S, Leis A, Bythell-Douglas R, Murphy V, Sharp M, et al.
Elife
. 2020 Mar;
9.
PMID: 32167469
FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA repair pathway. It has been proposed that at stalled replication forks, monoubiquitinated-FANCD2 serves to...
6.
Tan W, van Twest S, Murphy V, Deans A
Front Cell Dev Biol
. 2020 Mar;
8:2.
PMID: 32117957
DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair...
7.
Jung M, Ramanagoudr-Bhojappa R, van Twest S, Rosti R, Murphy V, Tan W, et al.
Blood
. 2020 Feb;
135(18):1588-1602.
PMID: 32106311
Fanconi anemia (FA) is the most common genetic cause of bone marrow failure and is caused by inherited pathogenic variants in any of 22 genes. Of these, only FANCB is...
8.
Tan W, Murphy V, Charron A, van Twest S, Sharp M, Constantinou A, et al.
PLoS One
. 2020 Feb;
15(2):e0229000.
PMID: 32092106
Site-specific conjugation of ubiquitin onto a range of DNA repair proteins regulates their critical functions in the DNA damage response. Biochemical and structural characterization of these functions are limited by...
9.
Swuec P, Renault L, Borg A, Shah F, Murphy V, van Twest S, et al.
Cell Rep
. 2016 Dec;
18(3):611-623.
PMID: 27986592
Activation of the main DNA interstrand crosslink repair pathway in higher eukaryotes requires mono-ubiquitination of FANCI and FANCD2 by FANCL, the E3 ligase subunit of the Fanconi anemia core complex....
10.
van Twest S, Murphy V, Hodson C, Tan W, Swuec P, ORourke J, et al.
Mol Cell
. 2016 Dec;
65(2):247-259.
PMID: 27986371
Monoubiquitination and deubiquitination of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that is defective in the cancer predisposition syndrome Fanconi anemia (FA). The "FA core complex" contains...