Sylvia Andrzejewski
Overview
Explore the profile of Sylvia Andrzejewski including associated specialties, affiliations and a list of published articles.
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10
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1115
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Recent Articles
1.
Lagu B, Wu X, Kulkarni S, Paul R, Becherer J, Olson L, et al.
J Med Chem
. 2022 Jun;
65(13):9418-9446.
PMID: 35762533
CD38 is one of the major nicotinamide adenine dinucleotide (NAD)- and nicotinamide adenine dinucleotide phosphate (NADP)-consuming enzymes in mammals. NAD, NADP, and their reduced counterparts are essential coenzymes for numerous...
2.
Chen P, Katsuyama E, Satyam A, Li H, Rubio J, Jung S, et al.
Sci Adv
. 2022 Jun;
8(24):eabo4271.
PMID: 35704572
Infection is one of the major causes of mortality in patients with systemic lupus erythematosus (SLE). We previously found that CD38, an ectoenzyme that regulates the production of NAD, is...
3.
Hsu B, Tabaries S, Johnson R, Andrzejewski S, Senecal J, Lehuede C, et al.
Cell Rep
. 2019 Jun;
27(13):3902-3915.e6.
PMID: 31242422
Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions. We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) that promote liver...
4.
Andrzejewski S, Siegel P, St-Pierre J
Front Endocrinol (Lausanne)
. 2018 Sep;
9:372.
PMID: 30186229
Metformin is one of the most commonly prescribed medications for the treatment of type 2 diabetes. Numerous reports have suggested potential anti-cancerous and cancer preventive properties of metformin, although these...
5.
Bchir W, Dufour C, Ouellet C, Yan M, Tam I, Andrzejewski S, et al.
Endocrinology
. 2018 Apr;
159(5):2153-2164.
PMID: 29635284
Given the increasing prevalence of obesity and the metabolic syndrome, identification of intrinsic molecular programs responsible for ensuring fuel homeostasis and preventing metabolic disease is needed. We investigated whether the...
6.
Andrzejewski S, Klimcakova E, Johnson R, Tabaries S, Annis M, McGuirk S, et al.
Cell Metab
. 2017 Oct;
26(5):778-787.e5.
PMID: 28988825
Metabolic adaptations play a key role in fueling tumor growth. However, less is known regarding the metabolic changes that promote cancer progression to metastatic disease. Herein, we reveal that breast...
7.
Rabinovitch R, Samborska B, Faubert B, Ma E, Gravel S, Andrzejewski S, et al.
Cell Rep
. 2017 Oct;
21(1):1-9.
PMID: 28978464
Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems. Regulation of mitochondrially produced ROS is required for proper cellular function, adaptation...
8.
Dupuy F, Tabaries S, Andrzejewski S, Dong Z, Blagih J, Annis M, et al.
Cell Metab
. 2015 Sep;
22(4):577-89.
PMID: 26365179
Metabolic reprogramming is a hallmark of cellular transformation, yet little is known about metabolic changes that accompany tumor metastasis. Here we show that primary breast cancer cells display extensive metabolic...
9.
Andrzejewski S, Gravel S, Pollak M, St-Pierre J
Cancer Metab
. 2014 Sep;
2:12.
PMID: 25184038
Background: Metformin is widely used in the treatment of diabetes, and there is interest in 'repurposing' the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects...
10.
Gravel S, Andrzejewski S, Avizonis D, St-Pierre J
Metabolites
. 2014 Jun;
4(2):166-83.
PMID: 24957021
Mitochondria are a focal point in metabolism, given that they play fundamental roles in catabolic, as well as anabolic reactions. Alterations in mitochondrial functions are often studied in whole cells,...