Syed Murtuza Baker
Overview
Explore the profile of Syed Murtuza Baker including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
295
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Recent Articles
11.
Fadlullah M, Neo W, Lie-A-Ling M, Thambyrajah R, Patel R, Mevel R, et al.
Blood
. 2021 Sep;
139(3):343-356.
PMID: 34517413
In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise for the treatment of any ailment that relies on bone marrow or blood transplantation. To achieve this,...
12.
Pelzer D, Phipps L, Thuret R, Gallardo-Dodd C, Baker S, Dorey K
EMBO Rep
. 2021 Aug;
22(9):e50932.
PMID: 34427977
Xenopus tadpoles have the ability to regenerate their tails upon amputation. Although some of the molecular and cellular mechanisms that globally regulate tail regeneration have been characterised, tissue-specific response to...
13.
Bridoux L, Zarrineh P, Mallen J, Phuycharoen M, Latorre V, Ladam F, et al.
PLoS Genet
. 2020 Dec;
16(12):e1009162.
PMID: 33315856
Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and...
14.
Nelson L, Tighe A, Golder A, Littler S, Bakker B, Moralli D, et al.
Nat Commun
. 2020 Feb;
11(1):822.
PMID: 32054838
High-grade serous ovarian carcinoma is characterised by TP53 mutation and extensive chromosome instability (CIN). Because our understanding of CIN mechanisms is based largely on analysing established cell lines, we developed...
15.
Yang S, Andrabi M, Biss R, Baker S, Iqbal M, Sharrocks A
Cell Rep
. 2019 Jun;
27(11):3215-3227.e6.
PMID: 31189106
Embryonic stem cells (ESCs) must transition through a series of intermediate cell states before becoming terminally differentiated. Here, we investigated the early events in this transition by determining the changes...
16.
Baker S, Rogerson C, Hayes A, Sharrocks A, Rattray M
Nucleic Acids Res
. 2018 Oct;
47(2):e10.
PMID: 30335168
ATAC-seq is a recently developed method to identify the areas of open chromatin in a cell. These regions usually correspond to active regulatory elements and their location profile is unique...
17.
Tsigkinopoulou A, Baker S, Breitling R
Trends Biotechnol
. 2017 Jan;
35(6):518-529.
PMID: 28094080
Although there is still some skepticism in the biological community regarding the value and significance of quantitative computational modeling, important steps are continually being taken to enhance its accessibility and...
18.
Baker S, Poskar C, Schreiber F, Junker B
BMC Bioinformatics
. 2015 Apr;
16:104.
PMID: 25886743
Background: Utilizing kinetic models of biological systems commonly require computational approaches to estimate parameters, posing a variety of challenges due to their highly non-linear and dynamic nature, which is further...
19.
Baker S, Poskar C, Schreiber F, Junker B
Bioinformatics
. 2013 Feb;
29(8):1052-9.
PMID: 23434837
Motivation: In systems biology, kinetic models represent the biological system using a set of ordinary differential equations (ODEs). The correct values of the parameters within these ODEs are critical for...
20.
Baker S, Poskar C, Junker B
EURASIP J Bioinform Syst Biol
. 2011 Oct;
2011(1):7.
PMID: 21989173
In systems biology, experimentally measured parameters are not always available, necessitating the use of computationally based parameter estimation. In order to rely on estimated parameters, it is critical to first...