David R Withers
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Explore the profile of David R Withers including associated specialties, affiliations and a list of published articles.
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86
Citations
3333
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Recent Articles
1.
Diers A, Guo Q, Li Z, Richardson E, Idris S, Willis C, et al.
Cancer Res Commun
. 2025 Jan;
5(2):327-338.
PMID: 39881590
This study utilized a novel photoconvertible mouse tumor model to track immune cell trafficking upon treatment with an investigational viral immunotherapy (CAN-2409), revealing enhanced T-cell responses after viral immunotherapy associated...
2.
Stockis J, Yip T, Moreno-Vicente J, Burton O, Samarakoon Y, Schuijs M, et al.
Sci Immunol
. 2024 Jul;
9(97):eadl1903.
PMID: 39028828
Regulatory T cells (T) control adaptive immunity and restrain type 2 inflammation in allergic disease. Interleukin-33 promotes the expansion of tissue-resident T and group 2 innate lymphoid cells (ILC2s); however,...
3.
Lee C, Clatworthy M, Withers D
Immunol Cell Biol
. 2024 Jun;
102(8):665-679.
PMID: 38853634
The ability to characterize immune cells and explore the molecular interactions that govern their functions has never been greater, fueled in recent years by the revolutionary advance of single-cell analysis...
4.
Dean I, Kennedy B, Li Z, Berditchevski F, Withers D
STAR Protoc
. 2024 Mar;
5(2):102956.
PMID: 38512866
Preclinical tumor models have advanced our understanding of the tumor microenvironment. However, the temporal dynamics of cellular recruitment and retention within these models is poorly understood. Here, we present a...
5.
Lee C, Kennedy B, Richoz N, Dean I, Tuong Z, Gaspal F, et al.
Nat Commun
. 2024 Jan;
15(1):682.
PMID: 38267413
Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule...
6.
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Dean I, Lee C, Tuong Z, Li Z, Tibbitt C, Willis C, et al.
Nat Commun
. 2024 Jan;
15(1):683.
PMID: 38267402
Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mechanistic underpinning...
7.
Tacho-Pinot R, Stamper C, King J, Matei-Rascu V, Richardson E, Li Z, et al.
Cell Rep
. 2023 Nov;
42(11):113425.
PMID: 37950867
Innate lymphoid cells (ILCs) are tissue-resident effector cells with roles in tissue homeostasis, protective immunity, and inflammatory disease. Group 3 ILCs (ILC3s) are classically defined by the master transcription factor...
8.
Anstee J, Feehan K, Opzoomer J, Dean I, Muller H, Bahri M, et al.
Dev Cell
. 2023 Jul;
58(17):1548-1561.e10.
PMID: 37442140
Tumor-associated macrophages (TAMs) are a heterogeneous population of cells that facilitate cancer progression. However, our knowledge of the niches of individual TAM subsets and their development and function remain incomplete....
9.
Clement M, Ladell K, Miners K, Marsden M, Chapman L, Cardus Figueras A, et al.
Elife
. 2023 Jul;
12.
PMID: 37440306
Inhibitory CD4 T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the...
10.
Kennedy B, Dean I, Withers D
Discov Immunol
. 2023 Apr;
2(1):kyad004.
PMID: 37008996
The clinical success of immune checkpoint blockade in some patients has transformed treatment approaches in cancer and offers the hope of durable curative responses. Building from studies of chronic infection,...