Swamy R Adapa
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Explore the profile of Swamy R Adapa including associated specialties, affiliations and a list of published articles.
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19
Citations
765
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Recent Articles
1.
Adapa S, Meshram P, Sami A, Jiang R
Biomolecules
. 2024 Aug;
14(8).
PMID: 39199347
The liver, a pivotal organ in human metabolism, serves as a primary site for heme biosynthesis, alongside bone marrow. Maintaining precise control over heme production is paramount in healthy livers...
2.
Adapa S, Sami A, Meshram P, Ferreira G, Jiang R
Genes (Basel)
. 2024 Jul;
15(7).
PMID: 39062740
Heme, an iron-containing tetrapyrrole, is essential in almost all organisms. Heme biosynthesis needs to be precisely regulated particularly given the potential cytotoxicity of protoporphyrin IX, the intermediate preceding heme formation....
3.
McMinds R, Jiang R, Adapa S, Ruhs E, Munds R, Leiding J, et al.
Proc Biol Sci
. 2024 Jun;
291(2025):20240535.
PMID: 38917861
Empirical data relating body mass to immune defence against infections remain limited. Although the metabolic theory of ecology predicts that larger organisms would have weaker immune responses, recent studies have...
4.
Adapa S, Hunter G, Amin N, Marinescu C, Borsky A, Sagatys E, et al.
Life Sci Alliance
. 2024 May;
7(8).
PMID: 38803226
No abstract available.
5.
Muneer A, Adapa S, Silbert S, Scanlan K, Vore H, Cannons A, et al.
Emerg Infect Dis
. 2024 Apr;
30(6):1214-1217.
PMID: 38662728
During May-July 2023, a cluster of 7 patients at local hospitals in Florida, USA, received a diagnosis of Plasmodium vivax malaria. Whole-genome sequencing of the organism from 4 patients and...
6.
Adapa S, Hunter G, Amin N, Marinescu C, Borsky A, Sagatys E, et al.
Life Sci Alliance
. 2024 Apr;
7(7).
PMID: 38649187
All cancer cells reprogram metabolism to support aberrant growth. Here, we report that cancer cells employ and depend on imbalanced and dynamic heme metabolic pathways, to accumulate heme intermediates, that...
7.
Lucky A, Wang C, Li X, Chim-Ong A, Adapa S, Quinlivan E, et al.
Nucleic Acids Res
. 2023 Apr;
51(8):3918-3933.
PMID: 37026483
DNA modifications are critical in fine-tuning the biological processes in model organisms. However, the presence of cytosine methylation (5mC) and the function of the putative DNA methyltransferase, PfDNMT2, in the...
8.
Sacco M, Wang S, Adapa S, Zhang X, Lewandowski E, Gongora M, et al.
Nat Commun
. 2022 Jul;
13(1):4370.
PMID: 35902581
Treatment with β-lactam antibiotics, particularly cephalosporins, is a major risk factor for Clostridioides difficile infection. These broad-spectrum antibiotics irreversibly inhibit penicillin-binding proteins (PBPs), which are serine-based enzymes that assemble the...
9.
Zhang M, Wang C, Oberstaller J, Thomas P, Otto T, Casandra D, et al.
Nat Commun
. 2021 Jul;
12(1):4563.
PMID: 34315897
The emergence and spread of Plasmodium falciparum parasites resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. Here, we...
10.
Wang C, Gibbons J, Adapa S, Oberstaller J, Liao X, Zhang M, et al.
J Genet Genomics
. 2020 Dec;
47(9):513-521.
PMID: 33272860
The human malaria parasite Plasmodium falciparum thrives in radically different host environments in mosquitoes and humans, with only a limited set of transcription factors. The nature of regulatory elements or...