Suzanne J Randle
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Explore the profile of Suzanne J Randle including associated specialties, affiliations and a list of published articles.
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16
Citations
845
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Recent Articles
1.
Chou D, Furlong B, Posey R, Kyprianou C, OSullivan L, David R, et al.
Nat Commun
. 2022 Oct;
13(1):6021.
PMID: 36224199
Drug-induced cytopenias are a prevalent and significant issue that worsens clinical outcomes and hinders the effective treatment of cancer. While reductions in blood cell numbers are classically associated with traditional...
2.
Spagnol V, Oliveira C, Randle S, Passos P, Correia C, Simaroli N, et al.
Biochim Biophys Acta Gen Subj
. 2020 Oct;
1865(1):129754.
PMID: 33010352
Background: Ubiquitously eXpressed Transcript isoform 2 (UXTV2) is a prefoldin-like protein involved in NF-κB signaling, apoptosis, and the androgen and estrogen response. UXT-V2 is a cofactor in the NF-κB transcriptional...
3.
Rathje C, Randle S, Al Rawi S, Skinner B, Nelson D, Majumdar A, et al.
Front Physiol
. 2019 Oct;
10:1278.
PMID: 31649556
Fbxo7 is the substrate-recognition subunit of an SCF-type ubiquitin E3 ligase complex. It has physiologically important functions in regulating mitophagy, proteasome activity and the cell cycle in multiple cell types,...
4.
Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway
Stott S, Randle S, Al Rawi S, Rowicka P, Harris R, Mason B, et al.
J Pathol
. 2019 May;
249(2):241-254.
PMID: 31144295
The field of Parkinson's disease research has been impeded by the absence of animal models that clearly phenocopy the features of this neurodegenerative condition. Mutations in FBXO7/PARK15 are associated with...
5.
St George-Hyslop P, Lin J, Miyashita A, Phillips E, Qamar S, Randle S, et al.
Brain Res
. 2018 May;
1693(Pt A):11-23.
PMID: 29723523
Many RNA binding proteins, including FUS, contain moderately repetitive, low complexity, intrinsically disordered domains. These sequence motifs have recently been found to underpin reversible liquid: liquid phase separation and gelation...
6.
Qamar S, Wang G, Randle S, Ruggeri F, Varela J, Lin J, et al.
Cell
. 2018 Apr;
173(3):720-734.e15.
PMID: 29677515
Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here,...
7.
Patel S, Randle S, Gibbs S, Cooke A, Laman H
Cell Mol Life Sci
. 2016 Dec;
74(8):1553-1566.
PMID: 27915416
G phase cell cycle proteins, such as cyclin-dependent kinase 6 (Cdk6) and its activating partners, the D-type cyclins, are important regulators of T-cell development and function. An F-box protein, called...
8.
Teixeira F, Randle S, Patel S, Mevissen T, Zenkeviciute G, Koide T, et al.
Biochem J
. 2016 Aug;
473(20):3563-3580.
PMID: 27503909
Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with alterations in red blood cell parameters. Point mutations...
9.
Randle S, Laman H
Curr Protein Pept Sci
. 2016 Mar;
18(7):715-724.
PMID: 26965690
Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)- type E3 ubiquitin ligase and also having SCF-independent activities. Mutations within FBXO7 have been found to cause...
10.
Randle S, Laman H
Semin Cancer Biol
. 2015 Sep;
36:3-17.
PMID: 26416465
F-box proteins (FBP) are the substrate specifying subunit of Skp1-Cul1-FBP (SCF)-type E3 ubiquitin ligases and are responsible for directing the ubiquitination of numerous proteins essential for cellular function. Due to...