Suzanne C Brewerton
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Explore the profile of Suzanne C Brewerton including associated specialties, affiliations and a list of published articles.
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12
Citations
467
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Recent Articles
1.
Dear A, Teng X, Ball S, Lewin J, Horne R, Clow D, et al.
Chem Sci
. 2024 May;
15(19):7229-7242.
PMID: 38756798
The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable...
2.
Drakakis G, Wafford K, Brewerton S, Bodkin M, Evans D, Bender A
ACS Chem Biol
. 2017 Apr;
12(6):1593-1602.
PMID: 28414209
In this work, we describe the computational ("in silico") mode-of-action analysis of CNS-active drugs, which is taking both multiple simultaneous hypotheses as well as sets of protein targets for each...
3.
Telenti A, Pierce L, Biggs W, di Iulio J, Wong E, Fabani M, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(42):11901-11906.
PMID: 27702888
We report on the sequencing of 10,545 human genomes at 30×-40× coverage with an emphasis on quality metrics and novel variant and sequence discovery. We find that 84% of an...
4.
Liggi S, Drakakis G, Hendry A, Hanson K, Brewerton S, Wheeler G, et al.
Mol Inform
. 2016 Aug;
32(11-12):1009-24.
PMID: 27481146
The simultaneous increase of computational power and the availability of chemical and biological data have contributed to the recent popularity of in silico bioactivity prediction algorithms. Such methods are commonly...
5.
Drakakis G, Koutsoukas A, Brewerton S, Bodkin M, Evans D, Bender A
Comb Chem High Throughput Screen
. 2015 Mar;
18(3):323-30.
PMID: 25747441
The increase of publicly available bioactivity data has led to the extensive development and usage of in silico bioactivity prediction algorithms. A particularly popular approach for such analyses is the...
6.
Liggi S, Drakakis G, Koutsoukas A, Cortes-Ciriano I, Martinez-Alonso P, Malliavin T, et al.
Future Med Chem
. 2014 Dec;
6(18):2029-56.
PMID: 25531967
Background: An in silico mechanism-of-action analysis protocol was developed, comprising molecule bioactivity profiling, annotation of predicted targets with pathways and calculation of enrichment factors to highlight targets and pathways more...
7.
Ravindranath A, Perualila-Tan N, Kasim A, Drakakis G, Liggi S, Brewerton S, et al.
Mol Biosyst
. 2014 Sep;
11(1):86-96.
PMID: 25254964
Integrating gene expression profiles with certain proteins can improve our understanding of the fundamental mechanisms in protein-ligand binding. This paper spotlights the integration of gene expression data and target prediction...
8.
OBoyle N, Brewerton S, Taylor R
J Chem Inf Model
. 2008 Jun;
48(6):1269-78.
PMID: 18533645
A continuing problem in protein-ligand docking is the correct relative ranking of active molecules versus inactives. Using the ChemScore scoring function as implemented in the GOLD docking software, we have...
9.
Brewerton S
Curr Opin Drug Discov Devel
. 2008 Apr;
11(3):356-64.
PMID: 18428089
The use of structure-based virtual screening to predict small-molecule binding in a target active site is an increasingly popular approach in drug discovery programs. As the number of structures of...
10.
Hartshorn M, Verdonk M, Chessari G, Brewerton S, Mooij W, Mortenson P, et al.
J Med Chem
. 2007 Feb;
50(4):726-41.
PMID: 17300160
A procedure for analyzing and classifying publicly available crystal structures has been developed. It has been used to identify high-resolution protein-ligand complexes that can be assessed by reconstructing the electron...