Suzanne Ackloo
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Explore the profile of Suzanne Ackloo including associated specialties, affiliations and a list of published articles.
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40
Citations
580
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Recent Articles
1.
Uguen M, Shell D, Silva M, Deng Y, Li F, Szewczyk M, et al.
Nat Commun
. 2025 Feb;
16(1):1905.
PMID: 39994194
A promising drug target, SETDB1, is a dual methyl-lysine (Kme) reader and methyltransferase implicated in cancer and neurodegenerative disease progression. To help understand the role of the triple Tudor domain...
2.
Wang X, Sun J, Ahmad S, Yang D, Li F, Chan U, et al.
bioRxiv
. 2025 Feb;
PMID: 39896675
We report an enantioselective protein affinity selection mass spectrometry screening approach (EAS-MS) that enables the detection of weak binders, informs about selectivity, and generates orthogonal confirmation of binding. After method...
3.
Mettu A, Glavatskikh M, Wang X, Lara Ordonez A, Li F, Chau I, et al.
Chem Sci
. 2025 Jan;
16(8):3430-3439.
PMID: 39877816
Critical Assessment of Computational Hit-Finding Experiments (CACHE) Challenges emerged as real-life stress tests for computational hit-finding strategies. In CACHE Challenge #1, 23 participants contributed their original workflows to identify small-molecule...
4.
Tredup C, Ackloo S, Beck H, Brown P, Bullock A, Ciulli A, et al.
RSC Med Chem
. 2024 Dec;
16(2):457-464.
PMID: 39618964
Target 2035 is a global initiative that seeks to identify a pharmacological modulator of most human proteins by the year 2035. As part of an ongoing series of annual updates...
5.
Mabanglo M, Wilson B, Noureldin M, Kimani S, Mamai A, Krausser C, et al.
Nat Commun
. 2024 Nov;
15(1):10165.
PMID: 39580491
Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets for more than two decades. However, only a handful of E3 ligase substrate receptors have been efficiently used....
6.
Li F, Ackloo S, Arrowsmith C, Ban F, Barden C, Beck H, et al.
J Chem Inf Model
. 2024 Nov;
64(22):8521-8536.
PMID: 39499532
The CACHE challenges are a series of prospective benchmarking exercises to evaluate progress in the field of computational hit-finding. Here we report the results of the inaugural CACHE challenge in...
7.
Ackloo S, Li F, Szewczyk M, Seitova A, Loppnau P, Zeng H, et al.
J Med Chem
. 2024 Nov;
68(2):1092-1112.
PMID: 39495097
Target class-focused drug discovery has a strong track record in pharmaceutical research, yet public domain data indicate that many members of protein families remain unliganded. Here we present a systematic...
8.
Uguen M, Shell D, Silva M, Deng Y, Li F, Szewczyk M, et al.
bioRxiv
. 2024 Oct;
PMID: 39386588
A promising drug target, SETDB1, is a dual Kme reader and methyltransferase, which has been implicated in cancer and neurodegenerative disease progression. To help understand the role of the triple...
9.
Wolf E, Herasymenko O, Kutera M, Lento C, Arrowsmith C, Ackloo S, et al.
Anal Chem
. 2024 Jul;
96(32):13015-13024.
PMID: 39074309
Hydrogen-deuterium eXchange mass spectrometry (HDX-MS) is increasingly used in drug development to locate binding sites and to identify allosteric effects in drug/target interactions. However, the potential of this technique to...
10.
Eguida M, Bret G, Sindt F, Li F, Chau I, Ackloo S, et al.
J Chem Inf Model
. 2024 Jun;
64(13):5344-5355.
PMID: 38916159
We herewith applied a generic hit identification method (POEM) for difficult targets of known three-dimensional structure, relying on the simple knowledge of physicochemical and topological properties of a user-selected cavity....