Sushma Nagaraja Grellscheid
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Explore the profile of Sushma Nagaraja Grellscheid including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Moya-Molina M, Dorgau B, Flood E, Letteboer S, Lorentzen E, Coxhead J, et al.
Cell Death Dis
. 2024 Oct;
15(10):721.
PMID: 39353897
Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is highly regulated in tissue- and development-specific patterns. Retinal tissue exhibits one of the highest levels of AS....
2.
Gortler F, Mensching-Buhr M, Skaar O, Schrod S, Sterr T, Schafer A, et al.
Bioinformatics
. 2024 Jun;
40(Suppl 1):i100-i109.
PMID: 38940181
Motivation: The inference of cellular compositions from bulk and spatial transcriptomics data increasingly complements data analyses. Multiple computational approaches were suggested and recently, machine learning techniques were developed to systematically...
3.
Neves A, Cuesta I, Hjerde E, Klemetsen T, Salgado D, van Helden J, et al.
Front Public Health
. 2023 Dec;
11:1289945.
PMID: 38074768
The COVID-19 pandemic has exemplified the importance of interoperable and equitable data sharing for global surveillance and to support research. While many challenges could be overcome, at least in some...
4.
Ehrmann I, Crichton J, Gazzara M, James K, Liu Y, Nagaraja Grellscheid S, et al.
Elife
. 2019 Jan;
8.
PMID: 30674417
Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the retrogene encoding RBMXL2 blocks...
5.
Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson C, Lahat A, et al.
Nat Commun
. 2017 Jun;
8:15691.
PMID: 28608850
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial...
6.
Heberle A, Prentzell M, van Eunen K, Bakker B, Nagaraja Grellscheid S, Thedieck K
Mol Cell Oncol
. 2016 Jun;
2(2):e970489.
PMID: 27308421
Tumors are prime examples of cell growth in unfavorable environments that elicit cellular stress. The high metabolic demand and insufficient vascularization of tumors cause a deficiency of oxygen and nutrients....
7.
Ghosh P, Nagaraja Grellscheid S, Sowdhamini R
J Biomol Struct Dyn
. 2015 Sep;
34(9):1979-86.
PMID: 26414300
The Transformer2 (Tra2) proteins in humans are homologues of the Drosophila Tra2 protein. One of the two RNA-binding paralogs, Tra2β, has been very well-studied over the past decade, but not...
8.
Schmid R, Nagaraja Grellscheid S, Ehrmann I, Dalgliesh C, Danilenko M, Paronetto M, et al.
Nucleic Acids Res
. 2013 Sep;
41(22):10170-84.
PMID: 24038356
Meiosis requires conserved transcriptional changes, but it is not known whether there is a corresponding set of RNA splicing switches. Here, we used RNAseq of mouse testis to identify changes...
9.
Nagaraja Grellscheid S, Dalgliesh C, Rozanska A, Grellscheid D, Bourgeois C, Stevenin J, et al.
Nucleic Acids Res
. 2011 Jul;
39(18):8092-104.
PMID: 21724598
Tra2β regulates a number of splicing switches including activation of the human testis-specific exon HIPK3-T in the Homeodomain Interacting Protein Kinase 3 gene. By testing HIPK3-T exons of different intrinsic...
10.
Vukusic I, Nagaraja Grellscheid S, Wiehe T
Genomics
. 2007 Feb;
89(4):471-9.
PMID: 17276654
Genetic programming (GP) can be used to classify a given gene sequence as either constitutively or alternatively spliced. We describe the principles of GP and apply it to a well-defined...