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Susanna J Dunachie

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Recent Articles
11.
Ali M, Longet S, Neale I, Rongkard P, Chowdhury F, Hill J, et al.
Clin Exp Immunol . 2024 Apr; 218(1):78-92. PMID: 38642547
Objective: Obesity and type 2 diabetes (DM) are risk factors for severe coronavirus disease 2019 (COVID-19) outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral...
12.
Liu C, Das R, Dijokaite-Guraliuc A, Zhou D, Mentzer A, Supasa P, et al.
Nat Commun . 2024 Apr; 15(1):3284. PMID: 38627386
The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S)...
13.
Zhou D, Supasa P, Liu C, Dijokaite-Guraliuc A, Duyvesteyn H, Selvaraj M, et al.
Nat Commun . 2024 Mar; 15(1):2734. PMID: 38548763
Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for...
14.
Doran W, Tunnicliffe L, Muzambi R, Rentsch C, Bhaskaran K, Smeeth L, et al.
BMJ Open Diabetes Res Care . 2024 Jan; 12(1). PMID: 38272537
Introduction: 4.2 million individuals in the UK have type 2 diabetes, a known risk factor for dementia and mild cognitive impairment (MCI). Diabetes treatment may modify this association, but existing...
15.
Wagner G, Stanjek T, Albrecht D, Lipp M, Dunachie S, Foderl-Hobenreich E, et al.
Front Immunol . 2023 Dec; 14:1294113. PMID: 38146371
Introduction: The environmental bacterium causes the often fatal and massively underreported infectious disease melioidosis. Antigens inducing protective immunity in experimental models have recently been identified and serodiagnostic tools have been...
16.
Ratcliffe H, Tiley K, Longet S, Tonry C, Roarty C, Watson C, et al.
iScience . 2023 Dec; 26(12):108500. PMID: 38089581
SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection...
17.
Wang L, Nicols A, Turtle L, Richter A, Duncan C, Dunachie S, et al.
BMJ Med . 2023 Nov; 2(1):e000468. PMID: 38027416
The T cell memory response is a crucial component of adaptive immunity responsible for limiting or preventing viral reinfection. T cell memory after infection with the SARS-CoV-2 virus or vaccination...
18.
Meumann E, Limmathurotsakul D, Dunachie S, Wiersinga W, Currie B
Nat Rev Microbiol . 2023 Oct; 22(3):155-169. PMID: 37794173
Burkholderia pseudomallei, the causative agent of melioidosis, is found in soil and water of tropical and subtropical regions globally. Modelled estimates of the global burden predict that melioidosis remains vastly...
19.
Hornsby H, Nicols A, Longet S, Liu C, Tomic A, Angyal A, et al.
Nat Commun . 2023 Aug; 14(1):5065. PMID: 37604803
Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many individuals possessing hybrid immunity, generated through a combination of vaccination and infection. Concerns have been raised that omicron...
20.
Preechanukul A, Kronsteiner B, Saiprom N, Rochaikun K, Moonmueangsan B, Phunpang R, et al.
iScience . 2023 Jul; 26(8):107234. PMID: 37520720
NK cells are endowed with immunological memory to a range of pathogens but the development of NK cell memory in bacterial infections remains elusive. Here, we establish an assay inducing...