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Susan Service

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Articles 17
Citations 447
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Recent Articles
1.
Boltz T, Chu B, Liao C, Sealock J, Ye R, Majara L, et al.
bioRxiv . 2024 Sep; PMID: 39282356
We deployed the Blended Genome Exome (BGE), a DNA library blending approach that generates low pass whole genome (1-4× mean depth) and deep whole exome (30-40× mean depth) data in...
2.
Ganel L, Chen L, Christ R, Vangipurapu J, Young E, Das I, et al.
Hum Genomics . 2021 Jun; 15(1):34. PMID: 34099068
Background: Mitochondrial genome copy number (MT-CN) varies among humans and across tissues and is highly heritable, but its causes and consequences are not well understood. When measured by bulk DNA...
3.
Mooney J, Huber C, Service S, Sul J, Marsden C, Zhang Z, et al.
Am J Hum Genet . 2018 Nov; 103(5):707-726. PMID: 30401458
Most population isolates examined to date were founded from a single ancestral population. Consequently, there is limited knowledge about the demographic history of admixed population isolates. Here we investigate genomic...
4.
Congdon E, Service S, Wessman J, Seppanen J, Schonauer S, Miettunen J, et al.
PLoS One . 2012 Jul; 7(7):e38065. PMID: 22815688
Background: Investigation of the environmental influences on human behavioral phenotypes is important for our understanding of the causation of psychiatric disorders. However, there are complexities associated with the assessment of...
5.
Wessman J, Schonauer S, Miettunen J, Turunen H, Parviainen P, Seppanen J, et al.
PLoS One . 2012 Jul; 7(7):e33088. PMID: 22815673
Background: The object of this study was to identify temperament patterns in the Finnish population, and to determine the relationship between these profiles and life habits, socioeconomic status, and health....
6.
Levine A, Service S, Miller E, Reynolds S, Singer E, Shapshak P, et al.
Am J Med Genet B Neuropsychiatr Genet . 2012 May; 159B(6):669-83. PMID: 22628157
The neuropathogenesis of HIV-associated neurocognitive disorders (HAND) is unclear. Candidate gene studies have implicated genetic susceptibility loci within immune-related genes; however, these have not been reliably validated. Here, we employed...
7.
Jasinska A, Lin M, Service S, Choi O, DeYoung J, Grujic O, et al.
Hum Mol Genet . 2012 May; 21(15):3307-16. PMID: 22556363
Non-human primates provide genetic model systems biologically intermediate between humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (Chlorocebus aethiops sabaeus) are genetically homogeneous and large enough to...
8.
Jasinska A, Service S, Choi O, DeYoung J, Grujic O, Kong S, et al.
Hum Mol Genet . 2009 Aug; 18(22):4415-27. PMID: 19692348
Genome-wide gene expression studies may provide substantial insight into gene activities and biological pathways differing between tissues and individuals. We investigated such gene expression variation by analyzing expression profiles in...
9.
Jasinska A, Service S, Levinson M, Slaten E, Lee O, Sobel E, et al.
Mamm Genome . 2007 Jul; 18(5):347-60. PMID: 17629771
The spectacular progress in genomics increasingly highlights the importance of comparative biology in biomedical research. In particular, nonhuman primates, as model systems, provide a crucial intermediate between humans and mice....
10.
Service S, Sabatti C, Freimer N
Genet Epidemiol . 2007 Feb; 31(3):189-94. PMID: 17323370
Population isolates may be particularly useful for association studies of complex traits. This utility, however, largely depends on the transferability of tag SNPs chosen from reference samples, such as HapMap,...