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Joseph DeYoung

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Articles 18
Citations 1009
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Recent Articles
1.
Haghani A, Li C, Robeck T, Zhang J, Lu A, Ablaeva J, et al.
Science . 2023 Aug; 381(6658):eabq5693. PMID: 37561875
Using DNA methylation profiles ( = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we...
2.
Hilser J, Hartiala J, Sriprasert I, Kono N, Cai Z, Karim R, et al.
Clin Epigenetics . 2022 Jul; 14(1):90. PMID: 35850911
Background: Cardiovascular disease (CVD) remains the leading cause of death among postmenopausal women but standard primary prevention strategies in women are not as effective as in men. By comparison, the...
3.
Jasinska A, Haghani A, Zoller J, Li C, Arneson A, Ernst J, et al.
Geroscience . 2021 Sep; 44(2):699-717. PMID: 34591235
DNA methylation-based biomarkers of aging have been developed for many mammals but not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human primate model for biomedical studies....
4.
Jasinska A, Zelaya I, Service S, Peterson C, Cantor R, Choi O, et al.
Nat Genet . 2017 Oct; 49(12):1714-1721. PMID: 29083405
By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative...
5.
Olde Loohuis L, Vorstman J, Ori A, Staats K, Wang T, Richards A, et al.
Nat Commun . 2015 Jul; 6:7501. PMID: 26158538
Schizophrenia is a common complex disorder with polygenic inheritance. Here we show that by using an approach that compares the individual loads of rare variants in 1,042 schizophrenia cases and...
6.
Jasinska A, Lin M, Service S, Choi O, DeYoung J, Grujic O, et al.
Hum Mol Genet . 2012 May; 21(15):3307-16. PMID: 22556363
Non-human primates provide genetic model systems biologically intermediate between humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (Chlorocebus aethiops sabaeus) are genetically homogeneous and large enough to...
7.
Close T, Bhat P, Lonardi S, Wu Y, Rostoks N, Ramsay L, et al.
BMC Genomics . 2009 Dec; 10:582. PMID: 19961604
Background: High density genetic maps of plants have, nearly without exception, made use of marker datasets containing missing or questionable genotype calls derived from a variety of genic and non-genic...
8.
Saris C, Horvath S, van Vught P, van Es M, Blauw H, Fuller T, et al.
BMC Genomics . 2009 Aug; 10:405. PMID: 19712483
Background: Amyotrophic Lateral Sclerosis (ALS) is a lethal disorder characterized by progressive degeneration of motor neurons in the brain and spinal cord. Diagnosis is mainly based on clinical symptoms, and...
9.
Jasinska A, Service S, Choi O, DeYoung J, Grujic O, Kong S, et al.
Hum Mol Genet . 2009 Aug; 18(22):4415-27. PMID: 19692348
Genome-wide gene expression studies may provide substantial insight into gene activities and biological pathways differing between tissues and individuals. We investigated such gene expression variation by analyzing expression profiles in...
10.
Kerner B, Jasinska A, DeYoung J, Almonte M, Choi O, Freimer N
Am J Med Genet B Neuropsychiatr Genet . 2008 May; 150B(1):24-32. PMID: 18484081
We reported previously a significant linkage signal between psychotic bipolar disorder (BP) and microsatellite markers on chromosome 5q31-34 in the National Institute of Mental Health Bipolar Genetics Initiative (NIMH-BPGI) data...