Susan Malkiel
Overview
Explore the profile of Susan Malkiel including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
227
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0
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Recent Articles
1.
Hui-Yuen J, Jiang K, Malkiel S, Eberhard B, Walters H, Diamond B, et al.
Lupus Sci Med
. 2023 May;
10(1).
PMID: 37202122
Background: SLE is likely triggered by gene-environment interactions. We have shown that most SLE-associated haplotypes encompass genomic regions enriched for epigenetic marks associated with enhancer function in lymphocytes, suggesting genetic...
2.
Barlev A, Malkiel S, Kurata-Sato I, Dorjee A, Suurmond J, Diamond B
J Clin Invest
. 2022 Jul;
132(17).
PMID: 35819855
FcγRIIB is an inhibitory receptor expressed throughout B cell development. Diminished expression or function is associated with lupus in mice and humans, in particular through an effect on autoantibody production...
3.
Quach T, Huang W, Sahu R, Diadhiou C, Raparia C, Johnson R, et al.
JCI Insight
. 2022 Feb;
7(5).
PMID: 35104241
TNF inhibitors are widely used to treat inflammatory diseases; however, 30%-50% of treated patients develop new autoantibodies, and 0.5%-1% develop secondary autoimmune diseases, including lupus. TNF is required for formation...
4.
Atisha-Fregoso Y, Malkiel S, Harris K, Byron M, Ding L, Kanaparthi S, et al.
Arthritis Rheumatol
. 2020 Aug;
73(1):121-131.
PMID: 32755035
Objective: To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN). Methods: In a multicenter, randomized, open-label...
5.
Malkiel S, Barlev A, Atisha-Fregoso Y, Suurmond J, Diamond B
Front Immunol
. 2018 Mar;
9:427.
PMID: 29556239
Plasma cells (PCs) are responsible for the production of protective antibodies against infectious agents but they also produce pathogenic antibodies in autoimmune diseases, such as systemic lupus erythematosus (SLE). Traditionally,...
6.
Suurmond J, Calise J, Malkiel S, Diamond B
Curr Opin Immunol
. 2016 Aug;
43:1-7.
PMID: 27504587
IgG anti-DNA antibodies are both diagnostic and pathogenic for systemic lupus erythematosus (SLE). They contribute to tissue inflammation through direct tissue binding and to systemic inflammation through activation of Toll-like...
7.
Malkiel S, Jeganathan V, Wolfson S, Manjarrez Orduno N, Marasco E, Aranow C, et al.
Arthritis Rheumatol
. 2016 Apr;
68(9):2210-20.
PMID: 27059652
Objective: Antinuclear antibodies (ANAs) are diagnostic in several autoimmune disorders, yet the failure to achieve B cell tolerance in these diseases is still poorly understood. Although secreted ANAs detected by...
8.
Malkiel S, Kuhlow C, Mena P, Benach J
J Immunol
. 2008 Dec;
182(1):498-506.
PMID: 19109181
T cell-independent Abs are protective against Lyme disease and relapsing fever, illnesses caused by Borrelia spirochetes with distinct blood-borne phases of infection. To understand this protective response, we characterized splenic...