Susan A Shinton
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Explore the profile of Susan A Shinton including associated specialties, affiliations and a list of published articles.
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26
Citations
1416
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Recent Articles
1.
Hayakawa K, Zhou Y, Shinton S
Immun Ageing
. 2024 Apr;
21(1):22.
PMID: 38570827
Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1ZAP70CD5 B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1 alone. In mice,...
2.
Shinton S, Brill-Dashoff J, Hayakawa K
Sci Rep
. 2022 Sep;
12(1):14899.
PMID: 36050343
Newborns require early generation of effective innate immunity as a primary physiological mechanism for survival. The neonatal Lin28Let7 developmental pathway allows increased generation of Th2-type cells and B1a (B-1 B)...
3.
Hayakawa K, Li Y, Shinton S, Bandi S, Formica A, Brill-Dashoff J, et al.
Front Immunol
. 2019 Apr;
10:457.
PMID: 30930899
The Lin28bLet7 axis in fetal/neonatal development plays a role in promoting CD5 B1a cell generation as a B-1 B cell developmental outcome. Here we identify the Let7 target, Arid3a, as...
4.
Hayakawa K, Formica A, Nakao Y, Ichikawa D, Shinton S, Brill-Dashoff J, et al.
J Immunol
. 2018 Jun;
201(2):804-813.
PMID: 29898964
In mice, fetal/neonatal B-1 cell development generates murine CD5 B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a V11/D/J knock-in mouse line (V11t) that...
5.
Hayakawa K, Formica A, Zhou Y, Ichikawa D, Asano M, Li Y, et al.
J Exp Med
. 2017 Sep;
214(10):3067-3083.
PMID: 28878001
Although B cell development requires expression of the B cell antigen receptor (BCR), it remains unclear whether engagement of self-antigen provides a positive impact for most B cells. Here, we...
6.
Liu X, Li Y, Shinton S, Rhodes J, Tang L, Feng H, et al.
J Immunol
. 2017 Jul;
199(5):1706-1715.
PMID: 28739882
CD79a and CD79b proteins associate with Ig receptors as integral signaling components of the B cell Ag receptor complex. To study B cell development in zebrafish, we isolated orthologs of...
7.
Hayakawa K, Formica A, Brill-Dashoff J, Shinton S, Ichikawa D, Zhou Y, et al.
J Exp Med
. 2016 Dec;
213(13):3007-3024.
PMID: 27899442
In mice, generation of autoreactive CD5 B cells occurs as a consequence of BCR signaling induced by (self)-ligand exposure from fetal/neonatal B-1 B cell development. A fraction of these cells...
8.
Seiler C, Gebhart N, Zhang Y, Shinton S, Li Y, Ross N, et al.
PLoS One
. 2015 Jul;
10(7):e0131908.
PMID: 26161877
Genetic screens are a powerful tool to discover genes that are important in immune cell development and function. The evolutionarily conserved development of lymphoid cells paired with the genetic tractability...
9.
Li Y, Zhou Y, Tang L, Shinton S, Hayakawa K, Hardy R
Ann N Y Acad Sci
. 2015 May;
1362:8-15.
PMID: 25931205
Fluorescence-activated cell sorting (FACS)-purified pro-B cells from fetal liver and adult bone marrow generate B cells with distinct phenotypes: fetal cells generate few IgD(high) B cells and half express CD5,...
10.
Hayakawa K, Formica A, Colombo M, Ichikawa D, Shinton S, Brill-Dashoff J, et al.
Ann N Y Acad Sci
. 2015 Apr;
1362:250-5.
PMID: 25907284
B cells generated early during fetal/neonatal B-1 development in mice include autoreactive cells with detectable CD5 upregulation induced by B cell receptor (BCR) signaling (B1a cells). A fraction of B1a...