Sumito Ito
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Explore the profile of Sumito Ito including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
229
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Recent Articles
1.
Murata M, Okada K, Takahashi M, Ueyama-Toba Y, Ito S, Mizuguchi H
Toxicol Lett
. 2024 Oct;
401:158-169.
PMID: 39383894
Caco-2 cells, a human colorectal adenocarcinoma cell line, are widely used to model small intestinal epithelial cells in the drug development process because they can predict drug absorption with high...
2.
Ichikawa M, Akamine H, Murata M, Ito S, Takayama K, Mizuguchi H
Sci Rep
. 2021 Jun;
11(1):11670.
PMID: 34083621
Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly...
3.
Ito S, Lee W, Park J, Yasunaga M, Mori A, Ohtsuki S, et al.
J Pharm Sci
. 2020 Nov;
110(1):365-375.
PMID: 33159914
In predicting the hepatic elimination of compounds, the extended clearance concept has proven useful. Yet, its experimental proof was scarce partly due to the lack of models with the controlled...
4.
Takayama K, Negoro R, Yamashita T, Kawai K, Ichikawa M, Mori T, et al.
Cell Mol Gastroenterol Hepatol
. 2019 Jun;
8(3):513-526.
PMID: 31228606
Background & Aims: To develop an effective and safe orally administered drug, it is important to predict its intestinal absorption rate, intestinal first-pass effect, and drug-drug interactions of orally administered...
5.
Kito T, Ito S, Mizuno T, Maeda K, Kusuhara H
Drug Metab Pharmacokinet
. 2018 Dec;
34(1):87-94.
PMID: 30528339
The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic...
6.
Takano H, Ito S, Zhang X, Ito H, Zhang M, Suzuki H, et al.
J Pharm Sci
. 2017 May;
106(9):2558-2565.
PMID: 28499878
We synthesized [C]sulpiride as a positron emission tomography probe for investigating the drug distribution in the human body. [C]Sulpiride was injected to healthy male subjects in either tracer dose of...
7.
Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, et al.
J Pharm Sci
. 2017 May;
106(9):2524-2534.
PMID: 28456731
This study aimed to investigate the interactions of 3 anticoagulants, rivaroxaban, apixaban, and dabigatran, with 5 human solute carrier transporters, hOAT1, hOAT3, hOCT2, hOATP1B1, and hOATP1B3. Apixaban inhibited hOAT3, hOATP1B1,...
8.
Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, et al.
Drug Metab Dispos
. 2015 Apr;
43(7):1008-18.
PMID: 25908246
Organic anion-transporting polypeptide (OATP) 1A2 has the potential to be a target for central nervous system drug delivery due to its luminal localization at the human blood-brain barrier and broad...
9.
Seki C, Oh-Nishi A, Nagai Y, Minamimoto T, Obayashi S, Higuchi M, et al.
EJNMMI Res
. 2014 Jul;
4:24.
PMID: 25045603
Background: Abnormal behaviors of young patients after taking the anti-influenza agent oseltamivir (Tamiflu®, F. Hoffmann-La Roche, Ltd., Basel, Switzerland) have been suspected as neuropsychiatric adverse events (NPAEs). Immune response to...
10.
Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, et al.
Pharm Res
. 2013 Aug;
31(1):136-47.
PMID: 23907530
Purpose: Multidrug and toxin extrusion proteins (MATEs) are multispecific organic cation transporters mediating the efflux of various cationic drugs into the urine. The present study aimed at identifying endogenous compounds...