Sumeet K Singh
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Explore the profile of Sumeet K Singh including associated specialties, affiliations and a list of published articles.
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16
Citations
187
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Recent Articles
1.
Patel D, Yadav P, Singh S, Tanwar S, Sehrawat A, Khurana A, et al.
J Biochem Mol Toxicol
. 2023 Oct;
38(1):e23559.
PMID: 37840533
Doxorubicin (Dox) is an anthracycline antibiotic used to treat various cancers and shows severe toxicity in multiple organ systems, including kidneys. Evidence shows that betaine's antioxidant and anti-inflammatory properties could...
2.
Currie M, Singh S, Ji M, Chatterjee C
Methods
. 2023 May;
215:28-37.
PMID: 37244506
Histone post-translational modifications (PTMs) on lysine residues, including methylation, ubiquitylation, and sumoylation, have been studied using semisynthetic histones reconstituted into nucleosomes. These studies have revealed the in vitro effects of...
3.
Singh S, Reyna A, Xie X, Mao H, Ji M, Zheng N, et al.
Chem Commun (Camb)
. 2023 Mar;
59(27):4063-4066.
PMID: 36938583
An efficient total chemical synthesis of site-specifically sumoylated histone H4 was undertaken to generate homogenously modified mononucleosomes. These were tested as substrates in biochemical assays with the histone H2B-specific ubiquitin...
4.
Chatterjee C, Singh S
Org Biomol Chem
. 2022 Jul;
20(28):5500-5509.
PMID: 35786742
The tumor suppressor and master gene regulator protein p53 has been the subject of intense investigation for several decades due to its mutation in about half of all human cancers....
5.
Sahu I, Mali S, Sulkshane P, Xu C, Rozenberg A, Morag R, et al.
Nat Commun
. 2021 Oct;
12(1):6173.
PMID: 34702852
The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is usually found as a mixture of 30S, 26S, and 20S complexes. These complexes have common catalytic sites, which makes...
6.
Huang Y, Nawatha M, Livneh I, Rogers J, Sun H, Singh S, et al.
Chemistry
. 2020 Feb;
26(36):8022-8027.
PMID: 32105365
Messenger RNA display of peptides containing non-proteinogenic amino acids, referred to as RaPID system, has become one of the leading methods to express libraries consisting of more than trillion-members of...
7.
Eid E, Boross G, Sun H, Msallam M, Singh S, Brik A
Bioconjug Chem
. 2020 Feb;
31(3):889-894.
PMID: 32069038
Interferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like modifiers (ULM) family, which adopts a β-grasp fold domain(s) similar to ubiquitin (Ub) with only minor sequence homology. ISG15 consists...
8.
Sun H, Mali S, Singh S, Meledin R, Brik A, Kwon Y, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(16):7805-7812.
PMID: 30867293
One of the enigmas in the ubiquitin (Ub) field is the requirement for a poly-Ub chain as a proteasomal targeting signal. The canonical chain appears to be longer than the...
9.
Mali S, Singh S, Eid E, Brik A
J Am Chem Soc
. 2017 Mar;
139(14):4971-4986.
PMID: 28328208
Posttranslational modification of proteins by ubiquitin (Ub), i.e., ubiquitination, mediates a variety of cellular processes, including protein homeostasis, cell cycle, DNA repair, and viral infections. Understanding the molecular mechanism of...
10.
Singh S, Sahu I, Mali S, Hemantha H, Kleifeld O, Glickman M, et al.
J Am Chem Soc
. 2016 Dec;
138(49):16004-16015.
PMID: 27960333
Various hypotheses have been proposed regarding how chain length, linkage type, position on substrate, and susceptibility to deubiquitinases (DUBs) affect processing of different substrates by proteasome. Here we report a...