Sumeena Bhatia
Overview
Explore the profile of Sumeena Bhatia including associated specialties, affiliations and a list of published articles.
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11
Citations
528
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Recent Articles
1.
Watanabe M, Fujihara C, Radtke A, Chiang Y, Bhatia S, Germain R, et al.
J Exp Med
. 2017 Aug;
214(9):2795-2810.
PMID: 28768709
T cell-dependent germinal center (GC) responses require coordinated interactions of T cells with two antigen-presenting cell (APC) populations, B cells and dendritic cells (DCs), in the presence of B7- and...
2.
Lucas C, Cordero-Nieves H, Erbe R, McAlees J, Bhatia S, Hodes R, et al.
J Immunol
. 2012 Dec;
190(2):723-36.
PMID: 23241883
CD86 engagement on a CD40L/IL-4-primed murine B cell activates signaling intermediates that promote NF-κB activation to increase Oct-2 and mature IgG1 mRNA and protein expression, as well as the rate...
3.
Langer H, Choi E, Zhou H, Schleicher R, Chung K, Tang Z, et al.
Circ Res
. 2012 Mar;
110(9):1202-10.
PMID: 22456181
Rationale: Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The function of platelets in inflammatory and autoimmune pathologies...
4.
Bhatia S, Sun K, Almo S, Nathenson S, Hodes R
J Immunol
. 2010 Jan;
184(4):1821-8.
PMID: 20065109
Under steady-state conditions, B7-1 is present as a mixed population of noncovalent dimers and monomers on the cell surface. In this study, we examined the physiological significance of this unique...
5.
Chattopadhyay K, Bhatia S, Fiser A, Almo S, Nathenson S
J Immunol
. 2006 Sep;
177(6):3920-9.
PMID: 16951355
Inducible costimulator (ICOS) ligand (ICOSL), a B7-related transmembrane glycoprotein with extracellular IgV and IgC domains, binds to ICOS on activated T cells and delivers a positive costimulatory signal for optimal...
6.
Bhatia S, Edidin M, Almo S, Nathenson S
Immunol Lett
. 2006 Jan;
104(1-2):70-5.
PMID: 16413062
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is...
7.
Bhatia S, Edidin M, Almo S, Nathenson S
Proc Natl Acad Sci U S A
. 2005 Oct;
102(43):15569-74.
PMID: 16221763
The costimulatory ligands B7-1 and B7-2 are expressed on the surface of antigen-presenting cells and interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on...
8.
Dani A, Chaudhry A, Mukherjee P, Rajagopal D, Bhatia S, George A, et al.
J Cell Sci
. 2004 Aug;
117(Pt 18):4219-30.
PMID: 15316082
Antigen-presenting cells (APCs) are expected to present peptides from endocytosed proteins via major histocompatibility complex (MHC) class II (MHCII) molecules to T cells. However, a large proportion of peptides purified...
9.
Zhang X, Schwartz J, Guo X, Bhatia S, Cao E, Lorenz M, et al.
Immunity
. 2004 Mar;
20(3):337-47.
PMID: 15030777
PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular...
10.
Suresh R, Vig M, Bhatia S, Goodspeed E, John B, Kandpal U, et al.
J Immunol
. 2002 Oct;
169(8):4262-72.
PMID: 12370357
Modalities for inducing long-lasting immune responses are essential components of vaccine design. Most currently available immunological adjuvants empirically used for this purpose cause some inflammation, limiting clinical acceptability. We show...