Sulantha Mathotaarachchi
Overview
Explore the profile of Sulantha Mathotaarachchi including associated specialties, affiliations and a list of published articles.
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46
Citations
1602
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Recent Articles
1.
Wang Y, Ashton N, Therriault J, Benedet A, Macedo A, Pola I, et al.
Brain Commun
. 2025 Jan;
7(1):fcaf004.
PMID: 39845736
Blood-based biomarkers have been revolutionizing the detection, diagnosis and screening of Alzheimer's disease. Specifically, phosphorylated-tau variants (p-tau, p-tau and p-tau) are promising biomarkers for identifying Alzheimer's disease pathology. Antibody-based assays...
2.
Leuzy A, Raket L, Villemagne V, Klein G, Tonietto M, Olafson E, et al.
Alzheimers Dement
. 2024 Jul;
20(9):5833-5848.
PMID: 39041435
Introduction: Tau-positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer...
3.
Pascoal T, Chamoun M, Lax E, Wey H, Shin M, Ng K, et al.
Nat Commun
. 2022 Oct;
13(1):5833.
PMID: 36192402
No abstract available.
4.
Therriault J, Pascoal T, Savard M, Mathotaarachchi S, Benedet A, Chamoun M, et al.
Sci Transl Med
. 2022 Aug;
14(659):eabc8693.
PMID: 36001678
Alzheimer's disease (AD) phenotypes might result from differences in selective vulnerability. Evidence from preclinical models suggests that tau pathology has cell-to-cell propagation properties. Therefore, here, we tested the cell-to-cell propagation...
5.
Pascoal T, Chamoun M, Lax E, Wey H, Shin M, Ng K, et al.
Nat Commun
. 2022 Jul;
13(1):4171.
PMID: 35853847
Alzheimer's disease (AD) is characterized by the brain accumulation of amyloid-β and tau proteins. A growing body of literature suggests that epigenetic dysregulations play a role in the interplay of...
6.
Ashton N, Benedet A, Pascoal T, Karikari T, Lantero-Rodriguez J, Brum W, et al.
EBioMedicine
. 2022 Feb;
76:103836.
PMID: 35158308
Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD) and are seen to be increased in preclinical stage...
7.
Savard M, Pascoal T, Servaes S, Dhollander T, Iturria-Medina Y, Kang M, et al.
Elife
. 2022 Jan;
11.
PMID: 35073256
Recent studies suggest a framework where white-matter (WM) atrophy plays an important role in fronto-temporal dementia (FTD) pathophysiology. However, these studies often overlook the fact that WM tracts bridging different...
8.
Pascoal T, Benedet A, Ashton N, Kang M, Therriault J, Chamoun M, et al.
Nat Med
. 2021 Oct;
27(11):2048-2049.
PMID: 34654920
No abstract available.
9.
Therriault J, Pascoal T, Sefranek M, Mathotaarachchi S, Benedet A, Chamoun M, et al.
Ann Clin Transl Neurol
. 2021 Oct;
8(10):2083-2092.
PMID: 34617688
Objective: To investigate the relationship between the topography of amyloid-β plaques, tau neurofibrillary tangles, and the overlap between the two, with cognitive dysfunction in individuals without dementia. Methods: We evaluated...
10.
Pascoal T, Benedet A, Tudorascu D, Therriault J, Mathotaarachchi S, Savard M, et al.
Brain
. 2021 Sep;
144(11):3517-3528.
PMID: 34515754
Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology and for clinical trials. Although the available first-generation tau...