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Sukhan Kim

Explore the profile of Sukhan Kim including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 26
Citations 360
Followers 0
Related Specialties
Physiology
Neurology
Biology
Top 10 Co-Authors
Scott J Myers
Stephen F Traynelis
Hongjie Yuan
Christian Aalkjaer
Jing Zhang
James P Allen
Johannes R Lemke
Riley E Perszyk
Ebbe Boedtkjer
Kelsey A Nocilla
Published In
J Physiol
Cell Mol Life Sci
Hum Mol Genet
J Cereb Blood Flow Metab
ACS Chem Neurosci
Affiliations
Soon will be listed here.
Recent Articles
1.
Ligand distances as key predictors of pathogenicity and function in NMDA receptors
Montanucci L, Brunger T, Bhattarai N, Bosselmann C, Kim S, Allen J, et al.
Hum Mol Genet . 2024 Nov; 34(2):128-139. PMID: 39535073
Genetic variants in the genes GRIN1, GRIN2A, GRIN2B, and GRIN2D, which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and heterogeneous neurologic and neurodevelopmental disorders, including...
2.
Distances from ligands as main predictive features for pathogenicity and functional effect of variants in NMDA receptors
Montanucci L, Brunger T, Bhattarai N, Bosselmann C, Kim S, Allen J, et al.
medRxiv . 2024 May; PMID: 38766179
Genetic variants in genes , , , and , which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and heterogeneous neurologic diseases. Missense variants in these...
3.
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor
Xu Y, Song R, Perszyk R, Chen W, Kim S, Park K, et al.
Cell Mol Life Sci . 2024 Mar; 81(1):153. PMID: 38538865
N-methyl-D-aspartate receptors (NMDARs) are members of the glutamate receptor family and participate in excitatory postsynaptic transmission throughout the central nervous system. Genetic variants in GRIN genes encoding NMDAR subunits are...
4.
Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the -Methyl-d-aspartate Receptor
DErasmo M, Akins N, Ma P, Jing Y, Swanger S, Sharma S, et al.
ACS Chem Neurosci . 2023 Aug; 14(17):3059-3076. PMID: 37566734
Subunit-selective inhibition of -methyl-d-aspartate receptors (NMDARs) is a promising therapeutic strategy for several neurological disorders, including epilepsy, Alzheimer's and Parkinson's disease, depression, and acute brain injury. We previously described the...
5.
Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
Lewis S, Shetty S, Gamble S, Heim J, Zhao N, Stitt G, et al.
Orphanet J Rare Dis . 2023 Aug; 18(1):225. PMID: 37537625
Background: Mutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe global developmental delay/intellectual disability, epileptic encephalopathy, and cerebral palsy phenotypes....
6.
Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function
Myers S, Yuan H, Perszyk R, Zhang J, Kim S, Nocilla K, et al.
Hum Mol Genet . 2023 Jun; 32(19):2857-2871. PMID: 37369021
Advances in sequencing technology have generated a large amount of genetic data from patients with neurological conditions. These data have provided diagnosis of many rare diseases, including a number of...
7.
Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening
Xie L, McDaniel M, Perszyk R, Kim S, Cappuccio G, Shapiro K, et al.
Cell Mol Life Sci . 2023 Mar; 80(4):110. PMID: 37000222
The short pre-M1 helix within the S1-M1 linker (also referred to as the pre-M1 linker) between the agonist-binding domain (ABD, S1) and the M1 transmembrane helix of the NMDA receptor...
8.
Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions
Tang W, Beckley J, Zhang J, Song R, Xu Y, Kim S, et al.
Cell Mol Life Sci . 2023 Jan; 80(2):42. PMID: 36645496
N-methyl-D-aspartate receptors (NMDARs) play vital roles in normal brain functions (i.e., learning, memory, and neuronal development) and various neuropathological conditions, such as epilepsy, autism, Parkinson's disease, Alzheimer's disease, and traumatic...
9.
Compound-heterozygous GRIN2A null variants associated with severe developmental and epileptic encephalopathy
Strehlow V, Rieubland C, Gallati S, Kim S, Myers S, Peterson V, et al.
Epilepsia . 2022 Aug; 63(10):e132-e137. PMID: 35983985
We report on an 8-year-old girl with severe developmental and epileptic encephalopathy due to the compound heterozygous null variants p.(Gln661*) and p.(Leu830Profs*2) in GRIN2A resulting in a knockout of the...
10.
Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels
Majgaard J, Skov F, Kim S, Hjortdal V, Boedtkjer D
Physiol Rep . 2022 Aug; 10(16):e15401. PMID: 35980021
Spontaneous action potentials precede phasic contractile activity in human collecting lymphatic vessels. In this study, we investigated the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in human collecting lymphatics and...