Sudhir Chowdhry
Overview
Explore the profile of Sudhir Chowdhry including associated specialties, affiliations and a list of published articles.
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15
Citations
1622
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0
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Recent Articles
1.
Tang J, Weiser N, Wang G, Chowdhry S, Curtis E, Zhao Y, et al.
Nature
. 2024 Nov;
635(8037):210-218.
PMID: 39506153
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival. At...
2.
Yaeger R, Mezzadra R, Sinopoli J, Bian Y, Marasco M, Kaplun E, et al.
Cancer Discov
. 2022 Nov;
13(1):41-55.
PMID: 36355783
Significance: Clinical resistance to KRASG12C-EGFR inhibition primarily prevents suppression of ERK signaling. Most resistance mechanisms are subclonal, whereas KRASG12C amplification rises over time to drive a higher portion of resistance....
3.
Al-Mubarak B, Bell K, Chowdhry S, Meakin P, Baxter P, McKay S, et al.
Redox Biol
. 2021 Oct;
47:102158.
PMID: 34626892
The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene expression drives cell-autonomous cytoprotection and also non-cell-autonomous protection of nearby neurons,...
4.
Bi J, Chowdhry S, Wu S, Zhang W, Masui K, Mischel P
Nat Rev Cancer
. 2019 Dec;
20(1):57-70.
PMID: 31806884
Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent technological advances, new insights into the molecular mechanisms underlying glioma metabolism are rapidly emerging. In this...
5.
Bi J, Ichu T, Zanca C, Yang H, Zhang W, Gu Y, et al.
Cell Metab
. 2019 Jul;
30(3):525-538.e8.
PMID: 31303424
Advances in DNA sequencing technologies have reshaped our understanding of the molecular basis of cancer, providing a precise genomic view of tumors. Complementary biochemical and biophysical perspectives of cancer point...
6.
Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, et al.
Nature
. 2019 Apr;
569(7757):570-575.
PMID: 31019297
Precision oncology hinges on linking tumour genotype with molecularly targeted drugs; however, targeting the frequently dysregulated metabolic landscape of cancer has proven to be a major challenge. Here we show...
7.
Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt C, et al.
Mol Cell Biol
. 2016 Jun;
36(18):2403-17.
PMID: 27354066
Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site...
8.
Hayes J, Chowdhry S, Dinkova-Kostova A, Sutherland C
Biochem Soc Trans
. 2015 Nov;
43(4):611-20.
PMID: 26551701
Nad(p)h: quinone oxidoreductase-1 (NQO1), whilst simultaneously causing inhibitory phosphorylation of GSK-3β at Ser(9). Together, these observations suggest that tBHQ can suppress the ability of SCF(β-TrCP) to target Nrf2 for proteasomal...
9.
Bell K, Al-Mubarak B, Martel M, McKay S, Wheelan N, Hasel P, et al.
Nat Commun
. 2015 May;
6:7066.
PMID: 25967870
Forebrain neurons have weak intrinsic antioxidant defences compared with astrocytes, but the molecular basis and purpose of this is poorly understood. We show that early in mouse cortical neuronal development...
10.
Meakin P, Chowdhry S, Sharma R, Ashford F, Walsh S, McCrimmon R, et al.
Mol Cell Biol
. 2014 Jun;
34(17):3305-20.
PMID: 24958099
Mice lacking the transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe nonalcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24...