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» Authors » Sudhakar Agnihothram

Sudhakar Agnihothram

Explore the profile of Sudhakar Agnihothram including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 25
Citations 2640
Followers 0
Related Specialties
Microbiology
General Medicine
Molecular Biology
Top 10 Co-Authors
Ralph S Baric
Vineet D Menachery
Lisa E Gralinski
Rachel L Graham
Boyd L Yount Jr
Eric F Donaldson
Trevor Scobey
Michael G Katze
Antonio Lanzavecchia
Mark T Heise
Published In
J Virol
mBio
Nat Med
J Infect Dis
Sci Data
Affiliations
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Recent Articles
11.
Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
Corti D, Zhao J, Pedotti M, Simonelli L, Agnihothram S, Fett C, et al.
Proc Natl Acad Sci U S A . 2015 Jul; 112(33):10473-8. PMID: 26216974
Middle East Respiratory Syndrome (MERS) is a highly lethal pulmonary infection caused by a previously unidentified coronavirus (CoV), likely transmitted to humans by infected camels. There is no licensed vaccine...
12.
Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection
Totura A, Whitmore A, Agnihothram S, Schafer A, Katze M, Heise M, et al.
mBio . 2015 May; 6(3):e00638-15. PMID: 26015500
Unlabelled: Toll-like receptors (TLRs) are sensors that recognize molecular patterns from viruses, bacteria, and fungi to initiate innate immune responses to invading pathogens. The emergence of highly pathogenic coronaviruses severe...
13.
A comprehensive collection of systems biology data characterizing the host response to viral infection
Aevermann B, Pickett B, Kumar S, Klem E, Agnihothram S, Askovich P, et al.
Sci Data . 2015 May; 1:140033. PMID: 25977790
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program...
14.
Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates
Selinger C, Tisoncik-Go J, Menachery V, Agnihothram S, Law G, Chang J, et al.
BMC Genomics . 2014 Dec; 15:1161. PMID: 25534508
Background: The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruses in humans. Clinical features...
15.
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses
Deng X, Agnihothram S, Mielech A, Nichols D, Wilson M, StJohn S, et al.
J Virol . 2014 Aug; 88(20):11825-33. PMID: 25100850
To combat emerging coronaviruses, developing safe and efficient platforms to evaluate viral protease activities and the efficacy of protease inhibitors is a high priority. Here, we exploit a biosafety level...
16.
A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant
Agnihothram S, Yount Jr B, Donaldson E, Huynh J, Menachery V, Gralinski L, et al.
mBio . 2014 Mar; 5(2):e00047-14. PMID: 24667706
Cross-species transmission of zoonotic coronaviruses (CoVs) can result in pandemic disease outbreaks. Middle East respiratory syndrome CoV (MERS-CoV), identified in 2012, has caused 182 cases to date, with ~43% mortality,...
17.
Human norovirus detection and production, quantification, and storage of virus-like particles
Debbink K, Costantini V, Swanstrom J, Agnihothram S, Vinje J, Baric R, et al.
Curr Protoc Microbiol . 2014 Feb; 31:15K.1.1-15K.1.45. PMID: 24510290
Human noroviruses constitute a significant worldwide disease burden. Each year, noroviruses cause over 267 million infections, deaths in over 200,000 children under the age of five, and over 50% of...
18.
Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity
Menachery V, Yount Jr B, Josset L, Gralinski L, Scobey T, Agnihothram S, et al.
J Virol . 2014 Jan; 88(8):4251-64. PMID: 24478444
Unlabelled: The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV) underscores the importance of understanding critical aspects of...
19.
Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses
Agnihothram S, Gopal R, Yount Jr B, Donaldson E, Menachery V, Graham R, et al.
J Infect Dis . 2013 Nov; 209(7):995-1006. PMID: 24253287
Background: Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing severe acute respiratory disease and pneumonia, with 44% mortality among 136 cases to date. Design of vaccines to limit...
20.
Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus
Josset L, Menachery V, Gralinski L, Agnihothram S, Sova P, Carter V, et al.
mBio . 2013 May; 4(3):e00165-13. PMID: 23631916
Unlabelled: A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the causative agent of a severe acute respiratory syndrome (SARS) resembling the illness caused by SARS...