Subramanian Rajagopalan
Overview
Explore the profile of Subramanian Rajagopalan including associated specialties, affiliations and a list of published articles.
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24
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1220
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Recent Articles
1.
Rane A, Rajagopalan S, Ahuja M, Thomas B, Chinta S, Andersen J
Neurotoxicology
. 2018 Feb;
65:166-173.
PMID: 29471019
The heat shock factor 90 (hsp90) complex has long been associated with neuropathological phenotypes linked to Parkinson's disease (PD) and its inhibition is neuroprotective in disease models. Hsp90 is conventionally...
2.
Chinta S, Woods G, Demaria M, Rane A, Zou Y, McQuade A, et al.
Cell Rep
. 2018 Feb;
22(4):930-940.
PMID: 29386135
Exposure to the herbicide paraquat (PQ) is associated with an increased risk of idiopathic Parkinson's disease (PD). Therapies based on PQ's presumed mechanisms of action have not, however, yielded effective...
3.
Borroni E, Bohrmann B, Grueninger F, Prinssen E, Nave S, Loetscher H, et al.
J Pharmacol Exp Ther
. 2017 Jun;
362(3):413-423.
PMID: 28642233
Monoamine oxidase B (MAO-B) has been implicated in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Increased MAO-B expression in astroglia has been observed adjacent to amyloid plaques...
4.
Das B, Rajagopalan S, Joshi G, Xu L, Luo D, Andersen J, et al.
Neuropharmacology
. 2017 May;
123:88-99.
PMID: 28533164
Here, we report the characterization of a novel hybrid D/D agonist and iron (II) specific chelator, D-607, as a multi-target-directed ligand against Parkinson's disease (PD). In our previously published report,...
5.
Siddiqui A, Rane A, Rajagopalan S, Chinta S, Andersen J
Neurobiol Dis
. 2016 May;
93:115-20.
PMID: 27185595
Loss of parkin E3 ligase activity as a result of parkin gene mutation in rare familial forms of Parkinson's disease (PD) has been shown to be detrimental to mitochondrial function...
6.
Rajagopalan S, Rane A, Chinta S, Andersen J
J Neurosci
. 2016 Jan;
36(4):1086-95.
PMID: 26818499
Significance Statement: Reductions in PHD2 activity within dopaminergic neurons in vivo and in cultured human induced pluripotent stem cell-derived neurons protects against mitochondrial stress-induced neurotoxicity. Protective effects are dependent on...
7.
Siddiqui A, Bhaumik D, Chinta S, Rane A, Rajagopalan S, Lieu C, et al.
J Neurosci
. 2015 Sep;
35(37):12833-44.
PMID: 26377470
Significance Statement: Mutations in PARK2 are generally associated with loss in ability to interact with PINK1, impacting on autophagic initiation. Our data suggest that, in the case of at least...
8.
Lieu C, Dewey C, Chinta S, Rane A, Rajagopalan S, Batir S, et al.
Brain Res
. 2014 Dec;
1591:111-7.
PMID: 25452026
Lithium has long been used as a treatment for the psychiatric disease bipolar disorder. However, previous studies suggest that lithium provides neuroprotective effects in neurodegenerative diseases such as Parkinson's disease...
9.
Shah M, Rajagopalan S, Xu L, Voshavar C, Shurubor Y, Beal F, et al.
J Neurochem
. 2014 May;
131(1):74-85.
PMID: 24848702
In this study, in vitro and in vivo experiments were carried out with the high-affinity multifunctional D2/D3 agonist D-512 to explore its potential neuroprotective effects in models of Parkinson's disease...
10.
Pharmacological prolyl hydroxylase domain inhibition as a therapeutic target for Parkinson's disease
Rajagopalan S, Chinta S, Andersen J
CNS Neurol Disord Drug Targets
. 2013 Sep;
13(1):120-5.
PMID: 24040809
Previously published data from our laboratory demonstrated that pharmacological inhibition of a family of enzymes known as prolyl hydroxylase domain proteins prevents neurotoxicity associated with the acute 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine intoxication...