Mitochondrial Quality Control Via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

Overview

Journal J Neurosci

Specialty Neurology

Date 2015 Sep 18

PMID 26377470

Citations 68

Authors

Almas Siddiqui

Dipa Bhaumik

Shankar J Chinta

Anand Rane

Subramanian Rajagopalan

Christopher A Lieu

Gordon J Lithgow

Julie K Andersen

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Mutations in PARK2 are generally associated with loss in ability to interact with PINK1, impacting on autophagic initiation. Our data suggest that, in the case of at least one parkin mutation, Q311X, detrimental effects are due to inhibition at the level of downstream lysosomal function. Mechanistically, this involves elevations in PARIS protein levels and subsequent effects on PGC1α-TFEB signaling that normally regulates mitochondrial quality control. Treatment with rapamycin independently restores PGC1α-TFEB signaling in a manner not requiring parkin activity and abrogates subsequent mitochondrial impairment and neuronal cell loss. Taken in total, our data suggest that the parkin Q311X mutation impacts on mitochondrial quality control via PARIS-mediated regulation of PGC1α-TFEB signaling and that this can be independently restored via rapamycin.

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