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Stuart Knechtle

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Articles 42
Citations 519
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Recent Articles
1.
Schwalb A, Anwar I, DeLaura I, Ladowski J, Yoon J, Belloni R, et al.
Front Transplant . 2024 Dec; 3:1494455. PMID: 39737411
Objective: Cardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is one of the leading causes of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized...
2.
Knechtle S, Jackson A, Ladowski J, Kwun J, Mangiola M, Tector A, et al.
Xenotransplantation . 2024 Oct; 31(5):e12884. PMID: 39410785
This report summarizes the content of a debate sponsored by eGenesis Bio, organized by the International Xenotransplantation Association (IXA), and attended by more than 150 delegates in the context of...
3.
Ladowski J, Chapman H, DeLaura I, Anwar I, Yoon J, Chen Z, et al.
HLA . 2024 Jul; 104(1):e15599. PMID: 39041289
Xenotransplantation is a potential option for individuals for whom an acceptable human allograft is unavailable. Individuals with broadly reactive HLA antibodies due to prior exposure to foreign HLA are potential...
4.
Perakslis E, McCourt B, Knechtle S
Front Transplant . 2024 Jul; 2:1178505. PMID: 38993911
The United States system of solid organ transplantation is overseen by the Organ Procurement Transplantation Network (OPTN). Recent announcements from the Health Resources and Services Administration (HRSA) indicate their clear...
5.
Schmitz R, Manook M, Fitch Z, Anwar I, DeLaura I, Olaso D, et al.
Front Transplant . 2024 Jul; 2:1230393. PMID: 38993898
Introduction: One-third of HLA-incompatible kidney transplant recipients experience antibody mediated rejection (AMR) with limited treatment options. This study describes a novel treatment strategy for AMR consisting of proteasome inhibition and...
6.
Knechtle S, Kwun J, Song S, Jackson A, Williams K, Sanoff S
Front Transplant . 2024 Jul; 2:1176796. PMID: 38993890
Using novel drugs targeting lymphocyte costimulation, cytokines, antibody, complement, and plasma cells, we have developed strategies in a non-human primate model to modulate the B cell response to incompatible kidney...
7.
Manook M, Olaso D, Anwar I, DeLaura I, Yoon J, Bae Y, et al.
Sci Transl Med . 2024 Jun; 16(751):eadk6152. PMID: 38865482
Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes of experimental xenotransplant. However, little is known about outcomes in sensitized recipients, a population that...
8.
Chandraker A, Regmi A, Gohh R, Sharma A, Woodle E, Ansari M, et al.
J Am Soc Nephrol . 2024 Mar; 35(5):618-629. PMID: 38470444
No abstract available.
9.
Luo X, Knechtle S
Kidney Int . 2024 Jan; 105(1):20-22. PMID: 38182290
In the study by Sasaki et al. in this issue, the authors studied infusions of ex vivo-expanded regulatory T cells in a highly clinically relevant nonhuman primate kidney transplant model....
10.
Duan M, Nguyen D, Joyner C, Saney C, Tipton C, Andrews J, et al.
Cell Rep . 2023 Jun; 42(7):112682. PMID: 37355988
Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell transcriptional resolution of 17,347 BM ASCs from...