Stuart Cobb
Overview
Explore the profile of Stuart Cobb including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
19
Citations
993
Followers
0
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Recent Articles
1.
Bracha S, Johnson H, Pranckevicius N, Catto F, Economides A, Litvinov S, et al.
Nat Microbiol
. 2024 Jul;
9(8):2051-2072.
PMID: 39075233
Delivering macromolecules across biological barriers such as the blood-brain barrier limits their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite that naturally travels from the human...
2.
Powers S, Likhite S, Gadalla K, Miranda C, Huffenberger A, Dennys C, et al.
Mol Ther
. 2023 Jul;
31(9):2767-2782.
PMID: 37481701
The AAV9 gene therapy vector presented in this study is safe in mice and non-human primates and highly efficacious without causing overexpression toxicity, a major challenge for clinical translation of...
3.
Zlatic S, Duong D, Gadalla K, Murage B, Ping L, Shah R, et al.
iScience
. 2022 Sep;
25(9):104966.
PMID: 36060065
MECP2 loss-of-function mutations cause Rett syndrome, a neurodevelopmental disorder resulting from a disrupted brain transcriptome. How these transcriptional defects are decoded into a disease proteome remains unknown. We studied the...
4.
Bernardo P, Cobb S, Coppola A, Tomasevic L, Di Lazzaro V, Bravaccio C, et al.
Ann Neurol
. 2020 Mar;
87(5):763-773.
PMID: 32129908
Objective: Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder due to pathogenic mutations in the MECP2 gene. Motor impairment constitutes the core diagnostic feature of RTT. Preclinical studies have...
5.
Velasco-Estevez M, Gadalla K, Linan-Barba N, Cobb S, Dev K, Sheridan G
Glia
. 2019 Oct;
68(2):356-375.
PMID: 31596529
Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS),...
6.
Turko P, Groberman K, Browa F, Cobb S, Vida I
Cereb Cortex
. 2018 Feb;
29(3):1230-1243.
PMID: 29425353
In the mammalian cortex, GABAergic and glutamatergic neurons represent 2 major neuronal classes, which establish inhibitory and excitatory synapses, respectively. Despite differences in their anatomy, physiology and developmental origin, both...
7.
Ross P, Guy J, Selfridge J, Kamal B, Bahey N, Tanner K, et al.
Hum Mol Genet
. 2017 Feb;
25(20):4389-4404.
PMID: 28173151
Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked MECP2 gene. MeCP2 protein is highly expressed in the nervous system and deficiency in the mouse...
8.
Leonard H, Cobb S, Downs J
Nat Rev Neurol
. 2016 Dec;
13(1):37-51.
PMID: 27934853
In the 50 years since Andreas Rett first described the syndrome that came to bear his name, and is now known to be caused by a mutation in the methyl-CpG-binding...
9.
Tragardh J, Robb G, Gadalla K, Cobb S, Travis C, Oppo G, et al.
Opt Lett
. 2015 Aug;
40(15):3484-7.
PMID: 26258338
We have developed a simple wavelength-tunable optical parametric generator (OPG), emitting broadband ultrashort pulses with peak wavelengths at 1530-1790 nm, for nonlinear label-free microscopy. The OPG consists of a periodically...
10.
Booker S, Pires N, Cobb S, Soares-da-Silva P, Vida I
Neuropharmacology
. 2015 Feb;
93:103-15.
PMID: 25656478
This study assessed the anticonvulsant and seizure generation effects of carbamazepine (CBZ), oxcarbazepine (OXC) and eslicarbazepine (S-Lic) in wild-type mice. Electrophysiological recordings were made to discriminate potential cellular and synaptic...