Stuart A Lipton
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Explore the profile of Stuart A Lipton including associated specialties, affiliations and a list of published articles.
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216
Citations
16763
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Recent Articles
11.
Tse W, Pochwat B, Szewczyk B, Misztak P, Bobula B, Tokarski K, et al.
Neuropharmacology
. 2023 Oct;
241:109729.
PMID: 37797736
In the search for new options for the pharmacological treatment of major depressive disorder, compounds with a rapid onset of action and high efficacy but lacking a psychotomimetic effect are...
12.
Doulias P, Yang H, Andreyev A, Dolatabadi N, Scott H, K Raspur C, et al.
Cell Chem Biol
. 2023 Jul;
30(8):965-975.e6.
PMID: 37478858
A causal relationship between mitochondrial metabolic dysfunction and neurodegeneration has been implicated in synucleinopathies, including Parkinson disease (PD) and Lewy body dementia (LBD), but underlying mechanisms are not fully understood....
13.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
14.
Ghatak S, Nakamura T, Lipton S
Front Neural Circuits
. 2023 Feb;
17:1099467.
PMID: 36817649
Alzheimer's disease (AD) is arguably the most common cause of dementia in the elderly and is marked by progressive synaptic degeneration, which in turn leads to cognitive decline. Studies in...
15.
Okuda K, Nakahara K, Ito A, Iijima Y, Nomura R, Kumar A, et al.
Nat Commun
. 2023 Feb;
14(1):621.
PMID: 36739439
DNA methyltransferases (DNMTs) catalyze methylation at the C5 position of cytosine with S-adenosyl-L-methionine. Methylation regulates gene expression, serving a variety of physiological and pathophysiological roles. The chemical mechanisms regulating DNMT...
16.
Yang H, Oh C, Amal H, Wishnok J, Lewis S, Schahrer E, et al.
Sci Adv
. 2022 Dec;
8(50):eade0764.
PMID: 36516243
Protein S-nitros(yl)ation (SNO) is a posttranslational modification involved in diverse processes in health and disease and can contribute to synaptic damage in Alzheimer's disease (AD). To identify SNO proteins in...
17.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles A, Medinas D, Gerakis Y, et al.
EMBO J
. 2022 Oct;
41(22):e111952.
PMID: 36314651
Aging is a major risk factor to develop neurodegenerative diseases and is associated with decreased buffering capacity of the proteostasis network. We investigated the significance of the unfolded protein response...
18.
Lipton S
Free Radic Biol Med
. 2022 Oct;
193(Pt 1):171-176.
PMID: 36243209
Emerging evidence indicates the importance of S-nitrosation in regulating protein function and activity. This chemical reaction has been termed protein S-nitrosylation to emphasize its biological importance as a posttranslational modification,...
19.
Oh C, Nakamura T, Beutler N, Zhang X, Pina-Crespo J, Talantova M, et al.
Nat Chem Biol
. 2022 Sep;
19(3):275-283.
PMID: 36175661
Prevention of infection and propagation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a high priority in the Coronavirus Disease 2019 (COVID-19) pandemic. Here we describe S-nitrosylation of multiple...
20.
Lipton S
Curr Opin Pharmacol
. 2022 Jul;
66:102267.
PMID: 35870288
Redox modifications are described that can be harnessed for the treatment of neurodegenerative disorders, including Alzheimer's disease (AD). The approach has shown potential therapeutic efficacy in AD in both transgenic...