Steven Y Qian
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Explore the profile of Steven Y Qian including associated specialties, affiliations and a list of published articles.
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46
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914
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Recent Articles
1.
Lu C, Xu W, Shah H, Liu B, Xu W, Sun L, et al.
ACS Appl Bio Mater
. 2022 Jan;
3(10):6865-6875.
PMID: 35019348
Three mononuclear or dinuclear bis(terpyridine) (tpy) iridium(III) complexes bearing pyren-1-yl (pyr) group(s) were synthesized. Their photophysical properties in water and in vitro photodynamic therapy (PDT) effects toward the human lung...
2.
Pang L, Shah H, Wang H, Shu D, Qian S, Sathish V
Mol Ther Nucleic Acids
. 2020 Nov;
22:222-235.
PMID: 33230429
Knocking down delta-5-desaturase (D5D) expression by D5D small interfering RNA (siRNA) has been reported that could redirect the cyclooxygenase-2 (COX-2)-catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation from producing prostaglandin E2 to 8-hydroxyoctanoic...
3.
Shah H, Pang L, Wang H, Shu D, Qian S, Sathish V
Nanomedicine
. 2020 Sep;
30:102298.
PMID: 32931930
8-Hydroxyoctanoic acid (8-HOA) produced through cyclooxygenase-2 (COX-2) catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation in delta-5-desaturase inhibitory (D5D siRNA) condition showed an inhibitory effect on breast cancer cell proliferation and migration. However,...
4.
Gao Y, Zhou S, Pang L, Yang J, Li H, Huo X, et al.
Free Radic Res
. 2019 Feb;
53(3):324-334.
PMID: 30773944
The thunder god vine (Tripterygium wilfordii Hook. F) is traditionally used for inflammation-related diseases in traditional Chinese medicine. In recent years, celastrol (a natural compound from the root of the...
5.
Gao Y, Zhou S, Xu Y, Sheng S, Qian S, Huo X
Nitric Oxide
. 2018 Dec;
83:33-39.
PMID: 30590117
Background: It has been widely accepted that angiogenesis plays fundamental roles in colorectal cancer development, and therapeutic targeting of this pathway has achieved promising outcome. Recent reports have highlighted the...
6.
Xu Y, Pang L, Wang H, Xu C, Shah H, Guo P, et al.
Redox Biol
. 2018 Dec;
21:101085.
PMID: 30584980
We have previously demonstrated that DGLA treatment along with Delta-5-Desaturase (D5D) siRNA in various types of cancer cells enhances the formation of 8-HOA from COX-2-catalyzed DGLA peroxidation, which in turn...
7.
Xu Y, Yang X, Gao D, Yang L, Miskimins K, Qian S
BMC Cancer
. 2018 Dec;
18(1):1268.
PMID: 30567534
Background: We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the production of the anti-cancer...
8.
Yang X, Xu Y, Gao D, Yang L, Qian S
Redox Biol
. 2018 Nov;
20:236-246.
PMID: 30384258
We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream ω - 6 dihomo-γ-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid...
9.
Xu Y, Yang X, Wang T, Yang L, He Y, Miskimins K, et al.
BMC Cancer
. 2018 Mar;
18(1):330.
PMID: 29587668
Background: Cyclooxygenase-2 (COX-2), the inducible COX form, is a bi-functional membrane-bound enzyme that typically metabolizes arachidonic acid (downstream ω-6 fatty acid) to form 2-series of prostaglandins known to be involved...
10.
Gao Y, Wang J, Zhou Y, Sheng S, Qian S, Huo X
Sci Rep
. 2018 Feb;
8(1):2732.
PMID: 29426902
Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined...